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Is There a Lithium Withdrawal Syndrome?

Published online by Cambridge University Press:  29 January 2018

A. J. Mander
A. J. Mander*
Affiliation:
University of Edinburgh Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH 10 5HF
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Extract

Patients who discontinued lithium after a mean of 29 ± 21 months prophylaxis were compared with a similar group who were not taking the drug; all had only been in hospital once, and satisfied DSM-III criteria for mania. During the first three months following withdrawal of lithium, significantly more patients relapsed than in the control group; after this period, the rate was identical. These findings suggest that lithium withdrawal exists as a clinical phenomenon and that a period of lithium treatment does not improve the long-term prognosis, once the drug has been stopped.

Type
Papers
Information
The British Journal of Psychiatry , Volume 149 , Issue 4 , October 1986 , pp. 498 - 501
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd ed.) (DSM-III). Washington DC: APA.Google Scholar
Baastrup, P. C., Poulsen, J. C., Schou, M., Thomsen, K. & Amdisen, A. (1970) Prophylactic lithium: double blind discontinuation in manic depressive and recurrent depressive disorders. The Lancet, ii, 326–330.CrossRefGoogle ScholarPubMed
Blackburn, I. M., Loudon, J. B. & Ashworth, C. M. (1977) A new scale for measuring mania. Psychological Medicine, 17, 453–458.CrossRefGoogle Scholar
Christodolou, G. N. & Lykouras, E. P. (1982) Abrupt lithium discontinuation in manic depressive patients. Acta Psychiatrica Scaninavica, 65, 310–314.CrossRefGoogle Scholar
Fleiss, J. L., Dunner, D. L., Stallone, F. & Fieve, R. R. (1976) The life table: a method of analysing longitudinal studies. Archives of General Psychiatry, 33, 107–112.CrossRefGoogle Scholar
Grof, P., Cakuls, P. & Dostal, T. (1970) Lithium dropouts. A follow-up study of patients who discontinued prophylactic treatment. International Pharmacopsychiatry, 5, 162–169.CrossRefGoogle Scholar
King, J. R. & Hulun, R. P. (1983) Withdrawal symptoms from lithium. Four case reports and a questionnaire study. British Journal of Psychiatry, 143, 30–35.CrossRefGoogle Scholar
Klein, H. E., Broucek, B. & Greil, W. (1981) Lithium withdrawal triggers psychotic states. British Journal of Psychiatry, 139, 255–256.CrossRefGoogle ScholarPubMed
Lapierre, Y. D., Gagnon, A. & Kokkinidb, L. (1980) Rapid recurrence of mania following lithium withdrawal. Biological Psychiatry, 15, 859–864.Google ScholarPubMed
Meua, P. I. (1970) Prophylactic lithium: a double blind discontinuation in manic-depressive and recurrent depressive disorders. British Journal of Psychiatry, 116, 621–624.Google Scholar
Sashidharan, S. P. & McGuire, R. J. (1983) Recurrence of affective illness after withdrawal of long-term lithium treatment. Acta Psychiatrica Scandinavica, 68, 126–133.CrossRefGoogle ScholarPubMed
Schou, M. (1980) Lithium Treatment of Manic Depressive Illness: A Practical Guide. Basel: Karger.Google Scholar
Schou, M., Thomson, K. & Baastrup, P. C. (1970) Studies on the course of recurrent endogenous affective disorder. Internationa1 Pharmacopsychiatry, 5, 100–106.CrossRefGoogle Scholar
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