Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-05T02:37:37.998Z Has data issue: false hasContentIssue false
  • English
  • Français

Iprindole and Imipramine in Non-Psychotic Depressed Out-Patients

Published online by Cambridge University Press:  29 January 2018

Karl Rickels ,
Hack R. Chung ,
Irma Csanalosi ,
Lester Sablosky  and
Joseph H. Simon
Karl Rickels
Affiliation:
University of Pennsylvania and Director of Psychopharmacology Research Unit
Hack R. Chung
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, U.S.A., 19104
Irma Csanalosi
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, U.S.A., 19104
Lester Sablosky
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, U.S.A., 19104
Joseph H. Simon
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, U.S.A., 19104
Get access Rights & Permissions [Opens in a new window]

Extract

In an earlier study this research group reported iprindole, a relatively new tricyclic derivative, to be an effective drug for use in depressed neurotic out-patients (ii). We found it to produce significantly greater improvement than placebo on a variety of outcome measures. Good response to iprindole as compared to placebo has also been reported by Hicks (5) and Daneman (3). Sterlin et al., comparing iprindole with amitriptyline in a relatively small patient sample, reported that iprindole, while faster acting, produced less overall improvement (15); differences in improvement did not, however, reach statistical significance.

Type
Papers
Information
The British Journal of Psychiatry , Volume 123 , Issue 574 , September 1973 , pp. 329 - 339
Copyright
Copyright © Royal College of Psychiatrists, 1973 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Ayd, F. J. (1969). ‘Clinical evaluation of a new tricyclic antidepressant, iprindole.’ Diseases of the Nervous System, 30, 818–23.Google ScholarPubMed
2. Company Brochure (1967).Google Scholar
3. Daneman, E. A. (1967). ‘Treatment of depressed patients with iprindole.’ Psychosomatics, 8, 216–21.Google Scholar
4. Hesbacher, P. T., Rickels, K., Hutchison, J., Raab, E., Sablosky, L., Whalen, E. M., and Phillips, F. J. (1970). ‘Setting, patient, and doctor effects on drug response in neurotic patients. II. Differential improvement.’ Psychopharmacologia (Berl.), 18, 209–26.CrossRefGoogle ScholarPubMed
5. Hicks, J. T. (1965). ‘Iprindole, a new anti-depressant for use in general office practice: A double-blind placebo controlled study.’ Illinois Medical Journal, 128, 622–6.Google Scholar
6. Höhn, R., Gross, G. M., Gross, M., and Lasagna, L. (1961). ‘A double-blind comparison of placebo and imipramine in the treatment of depressed patients in a state hospital.’ Journal of Psychiatric Research, 1, 76–91.CrossRefGoogle ScholarPubMed
7. Hollister, L. E., and Overall, J. E. (1965). ‘Reflections on the specificity of action of anti-depressants.’ Psychosomatics, 6, 361–5.CrossRefGoogle ScholarPubMed
8. Lipman, R. S., Covi, L., Rickels, K., Uhlenhuth, E. H., and Lazar, R. (1968). ‘Selected measures of change in outpatient drug evaluation’, in Psychopharmacology: A Review of Progress, 1957–1967 (eds. Efron, D. H., Cole, J. Levine, O., J., Wittenborn, J. R.). Public Health Service Publication No. 1836, pp. 249–54.Google Scholar
9. Overall, J. E., and Gorham, D. R. (1962). ‘The brief psychiatric rating scale.’ Psychological Reports, 10, 799–812.CrossRefGoogle Scholar
10. Rickels, K., Downing, R. W., and Spaeth, H. (in preparation). ‘The physician depression scale in psychotropic drug research.’ Google Scholar
11. Rickels, K., Gordon, P. E., Meckelnburg, R., Sablosky, L., Whalen, E. M., and Dion, H. (1968). ‘Iprindole in neurotic depressed general practice patients: A controlled study.’ Psychosomatics, 9, 208–14.CrossRefGoogle ScholarPubMed
12. Rickels, K., and Howard, K. (1970). ‘The physician questionnaire: A useful tool in psychiatric drug research.’ Psychopharmacologia (Berl.), 17, 338–44CrossRefGoogle ScholarPubMed
13. Rickels, K., DeSilverio, R., and Etemad, B. (1967). ‘Drug treatment in depression: Antidepressant or tranquilizer?’ Journal of the American Medical Association, 201, 675–81.Google ScholarPubMed
14. Rickels, K., Ward, C. H., and Schut, L. (1964). ‘Different populations, different drug responses: A comparative study of two antidepressants, each used in two different patient groups.’ American Journal of the Medical Sciences, 247, 328–35.CrossRefGoogle ScholarPubMed
15. Sterlin, C., Lehmann, H. E., Oliveros, R. F., Ban, T. A., and Saxena, B. M. (1968). ‘A preliminary investigation of WY-3263 versus amitriptyline in depressions.’ Current Therapeutic Research, 10, 576–82.Google ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.