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The Investigation of Homovanillic Acid in the Human Brain and its Correlation to Senile Dementia

Published online by Cambridge University Press:  29 January 2018

C. G. Gottfries ,
I. Gottfries  and
B. E. Roos
C. G. Gottfries
Affiliation:
östra Sjukhuset, The Mental Hospital of Malmô, Sweden
I. Gottfries
Affiliation:
Department of Psychiatry II, University of Lund, Sweden
B. E. Roos
Affiliation:
The Pharmacological Institute, University of Gothenburg, Sweden
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Extract

In a previous investigation, the concentration of homovanillic acid (HVA) seemed to be related to the degree of dementia (Gottfries et al., 1965). The object of the present work is the further study of the occurrence of HVA in the human brain, especially with regard to senile dementia. The hypothesis is that senile dementia is a disease with a disturbance in the monoamine metabolism, which is reflected in a reduction of HVA in the neostriatum.

Type
Biochemical Studies
Information
The British Journal of Psychiatry , Volume 115 , Issue 522 , May 1969 , pp. 563 - 574
Copyright
Copyright © Royal College of Psychiatrists, 1969 

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