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Interactions between Procyclidine and Neuroleptic Drugs

Some Pharmacological and Clinical Aspects

Published online by Cambridge University Press:  29 January 2018

J. S. Bamrah ,
V. Kumar ,
J. Krska  and
S. D. Soni
S. D. Soni*
Affiliation:
Prestwich Hospital
*
Research Department, Salford Health Authority, Prestwich Hospital, Prestwich, Manchester M25 7BL, UK
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Abstract

Procyclidine was administered to 25 chronic psychotic inpatients, stabilised on chlorpromazine, haloperidol or fluphenazine decanoate injection. We observed a significant reduction in mean serum levels of all three neuroleptic drugs which was reversed on stopping procyclidine and was Inversely correlated with mean serum procyclidine levels. No significant alterations occurred on the BPRS scores or in serum prolactin levels throughout the study In any of the three groups. Possible mechanisms of this interaction and its clinical relevance are discussed.

Type
Papers
Information
The British Journal of Psychiatry , Volume 149 , Issue 6 , December 1986 , pp. 726 - 733
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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