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Inhibition of In Vitro Production of Aldosterone by Manic-Depressive Sera

Published online by Cambridge University Press:  29 January 2018

R. P. Hullin ,
M. J. Levell ,
M. J. O'Brien  and
K. J. Toumba
R. P. Hullin
Affiliation:
Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
M. J. Levell
Affiliation:
Department of Chemical Pathology, Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
M. J. O'Brien
Affiliation:
Department of Biochemistry, Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
K. J. Toumba
Affiliation:
Department of Biochemistry, Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
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Summary

Serum samples from psychiatric patients were added to incubations of rat adrenal cortical cells synthesizing aldosterone. A high proportion of sera from patients with bipolar manic-depressive psychosis inhibited aldosterone production, but chronic in-patients without affective disorders gave few inhibitory sera. Inhibition was greatest in depression, lowest during normal affect. In one patient studied through 11 affective cycles the inhibitor score increased during transitions from mania to depression, showing a significant regression on time. The possible relationship of this in vitro phenomenon to the defect of aldosterone regulation in manic-depressive psychosis is discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 5 , May 1981 , pp. 373 - 380
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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References

Allsopp, M. N. E. Levell, M. J. Stitch, S. R. & Hullin, R. P. (1972) Aldosterone production rates in manic-depressive psychosis. British Journal of Psychiatry, 120, 399–404.Google Scholar
Aronoff, M. S. Evans, R. G. & Durell, J. (1970) Effect of lithium salts on electrolyte metabolism. Journal of Psychiatric Research, 8, 139–159.Google Scholar
Coghlan, J. P. Blair-West, J. R. Denton, D. A. Fei, D. T. Fernley, R. T. Hardy, K. J. McDougall, J. G., Puy, R. Robinson, P. M. Scoggins, B. A. & Wright, R. D. (1979) Control of aldosterone secretion. Journal of Endocrinology, 81, 55P–67P.Google Scholar
Grunebaum, H. & Altschule, M. D. (1950) Sodium concentration of thermal sweat in treated and untreated patients with mental disease. Archives of Neurology and Psychiatry, 63, 444–452.CrossRefGoogle Scholar
Hullin, R. P. Jerram, T. C. Lee, M. R. Levell, M. J. & Tyrer, S. P. (1977) Renin and aldosterone relationships in manic depressive psychosis. British Journal of Psychiatry, 131, 575–581.CrossRefGoogle ScholarPubMed
Levell, M. J. Allsopp, M. N. E. Stitch, S. R. & Hullin, R. P. (1971) The role of aldosterone in manic depressive psychosis. Journal of Endocrinology, 51, ix–ix.Google Scholar
McKenna, T. J., Island, D. P. Nicholson, W. E. & Liddle, G. W. (1979) Dopamine inhibits angiotensinstimulated aldosterone biosynthesis in bovine adrenal cells. Journal of Clinical Investigation, 64, 287–291.Google Scholar
Muller, J. (1970) Regulation of Aldosterone Biosynthesis, pp 32–38. Berlin: Springer-Verlag.Google Scholar
Murphy, B. E. P. Goodwin, F. & Bunney, W. Jr. (1969) Aldosterone and sodium response to lithium administration in man. Lancet, ii, 458–461.Google Scholar
O'Brien, M. J. Levell, M. J. & Hullin, R. P. (1979) Inhibition of aldosterone production in adrenal cell suspensions by serum from patients with manic-depressive psychosis. Journal of Endocrinology, 80, 41–50.Google Scholar
Peet, M. (1975) The potential difference across the rectal mucosa during depressive illness and lithium therapy. British Journal of Psychiatry, 127, 144–148.Google Scholar
Rees, J. R. Allsopp, M. N. E. & Hullin, R. P. (1974) Plasma concentration of tryptophan and other amino acids in manic-depressive patients. Psychological Medicine, 4, 334–337.Google Scholar
Ross, E. J. (1975) Aldosterone and Aldosteronism, pp 76 and 145. London: Lloyd-Luke.Google Scholar
Rylett, P. Dean, H. G. & Lee, M. R. (1975) Effect of deoxycortone-acetate salt and angiotensin-II amide on rat/brain tyrosine hydroxylase. Lancet, i, 854.Google Scholar
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