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Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever

Published online by Cambridge University Press:  03 January 2018

P. D. White ,
J. M. Thomas ,
J. Amess ,
D. H. Crawford ,
S. A. Grover ,
H. O. Kangro  and
A. W. Clare
P. D. White*
Affiliation:
St Bartholomew's and the Royal London Medical and Dental School, London
J. M. Thomas
Affiliation:
St Bartholomew's and the Royal London Medical and Dental School, London
J. Amess
Affiliation:
St Bartholomew's and the Royal London Medical and Dental School, London
D. H. Crawford
Affiliation:
Department of Virology, Royal Postgraduate Medical School, London
S. A. Grover
Affiliation:
Department of Virology, St Georges Hospital Medical School, London
H. O. Kangro
Affiliation:
St Bartholomew's and the Royal London Medical and Dental School, London
A. W. Clare
Affiliation:
St Bartholomew's and the Royal London Medical and Dental School, London
*
P. D. White, Department of Psychological Medicine. St Bartholomew's and the Royal London Medical and Dental School, London EC1A 7BE
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Abstract

Background

The role of viruses in the aetiology of both chronic fatigue syndrome (CFS) and depressive illness is uncertain.

Method

A prospective cohort study of 250 primary care patients, presenting with glandular fever or an ordinary upper respiratory tract infection (URTI).

Results

The incidence of an acute fatigue syndrome was 47% at onset, after glandular fever, compared with 20% with an ordinary URTI (relative risk 2.3, 95% CI 1.3–4.1). The acute fatigue syndrome lasted a median (interquartile range) of eight weeks (4–16) after glandular fever, but only three weeks (2–4) after an URTI. The prevalence of CFS was 9–22% six months after glandular fever, compared with 0–6% following an ordinary URTI, with relative risks of 2.7–5.1. The most conservative measure of the incidence of CFS was 9% after glandular fever, compared with no cases after an URTI. A conservative estimate is that glandular fever accounts for 3113 (95% C11698–4528) new cases of CFS per annum in England and Wales. New episodes of major depressive disorder were triggered by infection, especially the Epstein – Barr virus, but lasted a median of only three weeks. No psychiatric disorder was significantly more prevalent six months after onset than before.

Conclusions

Glandular fever is a significant risk factor for both acute and chronic fatigue syndromes. Transient new major depressive disorders occur close to onset, but are not related to any particular infection if they last more than a month.

Type
Papers
Information
The British Journal of Psychiatry , Volume 173 , Issue 6 , December 1998 , pp. 475 - 481
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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