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In Vivo Assay for Neuroleptic Receptor Binding in the Striatum

Positron Tomography in Humans

Published online by Cambridge University Press:  02 January 2018

H. Cambon ,
J. C. Baron ,
J. P. Boulenger ,
C. Loc'h ,
E. Zarifian  and
B. Maziere
H. Cambon
Affiliation:
Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique
J. C. Baron*
Affiliation:
Service Hospitalier Frédéric Joliot, CEA; Clinique des Maladies du Système nerveux, Hôpital de la Salpétrière, Paris
J. P. Boulenger
Affiliation:
Centre Psychiatrique Esquirol, Caen
C. Loc'h
Affiliation:
Service Hospitalier Frédéric Joliot, CEA
E. Zarifian
Affiliation:
Centre Psychiatrique Esquirol, Caen
B. Maziere
Affiliation:
Service Hospitalier Frédéric Joliot, CEA
*
Service Hospitalier Frédéric Joliot, CEA, Département de Biologie, 91406 Orsay, France
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Abstract

Using PET, we investigated the potency in six patients of therapeutic doses of neuroleptic drugs for preventing specific binding of trace doses of intravenously administered 76Br labelled bromospiperone to corpus striatum in vivo. Measured receptor occupancy showed a clear-cut dose-dependent saturation curve with increasing daily oral dose of neuroleptics, indicating the validity and reliability of the method when used as an in vivo radioreceptor assay. Following drug withdrawal in eight patients, recovery to normal or supranormal receptor availability occurred in a matter of days. The results demonstrate an approach that may help resolve controversies about, and design better strategies for, neuroleptic treatment schedules.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 6 , December 1987 , pp. 824 - 830
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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Footnotes

*

Presented in part at the Winter Workshop on Schizophrenia, Schiadming, Austria, 26–31 January 1986, and at the symposium Imagerie Fonctionnelle Cérébrale, Montpellier, France, 6–7 June 1986.

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