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Imprinting and Anticipation

Are They Relevant to Genetic Studies of Schizophrenia?

Published online by Cambridge University Press:  02 January 2018

Philip Asherson ,
Cathy Walsh ,
Julie Williams ,
Mathew Sargeant ,
Celia Taylor ,
Alison Clements ,
Michael Gill ,
Michael Owen  and
Peter McGuffin
Philip Asherson*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine
Cathy Walsh
Affiliation:
Genetics Section and Department of Neurosciences, Institute of Psychiatry
Julie Williams
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine
Mathew Sargeant
Affiliation:
St Tydfil's Hospital, Merthyr Tydfil
Celia Taylor
Affiliation:
Genetics Section and Department of Neurosciences, Institute of Psychiatry
Alison Clements
Affiliation:
Genetics Section and Department of Neurosciences, Institute of Psychiatry
Michael Gill
Affiliation:
Genetics Section and Department of Neurosciences, Institute of Psychiatry
Michael Owen
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine
Peter McGuffin
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine
*
∗Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
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Abstract

Among 29 multiply affected pedigrees, age of onset among parents and offspring was examined for evidence of both anticipation and genomic imprinting. The results do not suggest that either mechanism is operating in schizophrenia, but only very large effects can be confidently excluded.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 5 , May 1994 , pp. 619 - 624
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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