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Impairment of the Blood-Brain Barrier as an Aetiological Factor in Paranoid Psychosis

Published online by Cambridge University Press:  29 January 2018

Rolf Axelsson ,
Erik Martensson  and
Christer Alling
Rolf Axelsson
Affiliation:
Psychiatric Department III, Lillhagen Hospital, University of Goteborg, S-422 03 Hisings Backa, Sweden
Erik Martensson
Affiliation:
Psychiatric Department III, Lillhagen Hospital, University of Goteborg, Sweden
Christer Alling
Affiliation:
Department of Psychiatry and Neurochemistry, St Jorgen Hospital, University of Goteborg, Sweden
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Summary

Possible psychiatric implications of impairment of the blood-brain barrier were studied in 25 patients with paranoid psychosis. Determination of the ratio between the albumin concentrations in cerebrospinal fluid and serum showed increases, indicating impairment of the blood-brain barrier, in seven patients and normal values in 18. The two groups were compared for clinical, pharmacokinetic, neurophysiological and anamnestic variables. The highly significant finding that onset of psychosis had occurred, on average, 20 years earlier in the patients with impairment of the blood-brain barrier than in those without suggests that such impairment might influence the development of psychosis in predisposed individuals.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 3 , September 1982 , pp. 273 - 281
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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