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Hereditary Factors in the Pathogenesis of Affective Illnesses

Published online by Cambridge University Press:  29 January 2018

Barbara Jakimow-Venulet
Barbara Jakimow-Venulet*
Affiliation:
Department of Psychiatry, Psychoneurological Institute, 1/9 Sobieskiego Str., 02-957 Warsaw, Poland
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Summary

The purpose of the study was verification of a genetic distinction between bipolar and unipolar affective illness and investigation of hypotheses concerning the mode of genetic transmission of both illnesses. The investigation demonstrated a difference between a group of 150 probands with bipolar affective illness and 50 probands with unipolar affective illness.

A genetic-correlation analysis of both diseases showed that they are determined by different, partly correlated liabilities. Evaluation of the mode of inheritance suggests a multifactorial mode of inheritance of both affective illnesses: although genetic factors are of basic importance, continuously acting environmental factors also have a significant influence on the manifestation of the illness. The results suggest possible heterogeneity of both illnesses from the genetic standpoint.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 139 , Issue 5 , November 1981 , pp. 450 - 456
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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References

Angst, J. & Perris, C. (1968) Zur Nosologic endogener Depressionen. Vergleich der Ergebnisse zweier Untersuchungen. Archiv für Pscychiatrie und Nervenkrankheiten vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie, 210, 373–86.Google Scholar
Baker, M., Dorzab, J., Winokur, G. & Cadoret, R. (1972) Depressive disease: evidence favoring polygenic inheritance based on an analysis of ancestral cases. Archives of General Psychiatry, 27, 320–7.Google Scholar
Gershon, E. S. Bunney, W. E. Jr., Leckmann, J. F., Eerdewegh, M. U. & de Bauche, B. A. (1976) The inheritance of affective disorders: A review of data and hypotheses. Behavior Genetics, 6, 227–61.Google Scholar
Gindilis, W. M. (1979) The genetics of schizophrenia. Thesis, in Russian language. Institute of Psychiatry, Medical Sciences Academy, Moscow.Google Scholar
Grof, P., Angst, J. & Haines, T. (1974) The clinical course of depression: practical issues. In Classification and Prediction of Outcome of Depression (ed. Angst, J.), pp 141–8. Stuttgart and New York: F. K. Schattauer Verlag.Google Scholar
James, J. W. (1971) Frequency in relatives for an all-or-none trait. Annals of Human Genetics, 35, 47–9.Google Scholar
Larsson, T. & Sjogren, T. (1954) A methodological, psychiatric and statistical study of a large Swedish rural population. Acta Psychiatrica et Neurologica Scandinavica, Suppl 89.Google Scholar
Mendlewicz, J., Fleiss, J. L. & Fieve, R. R. (1972) Evidence for X linkage in the transmission of manic-depressive illness. The Journal of the American Medical Association, 222, 1624–7.Google Scholar
Mendlewicz, J., Fieve, R. R., Rainer, J. D. & Cataldo, M. (1973) Affective disorders on paternal and maternal sides. Observations in bipolar (manic-depressive) patients with and without a family history. British Journal of Psychiatry, 122, 31–4.Google Scholar
Morton, N. E. (1959) Genetics tests under incomplete ascertainment. American Journal of Human Genetics, 11, 1—16.Google Scholar
Morton, N. E. (1969) Segregation analysis. In Computer Applications in Genetics (ed. Morton, N. E.). Honolulu: University Hawaii Press.Google Scholar
Nance, W. E. & Corey, L. A. (1976) Genetics models for the analysis of data from the families of identical twins. Genetics, 83, 811–26.Google Scholar
Perris, C. (1968) The genetic transmission of depressive psychosis. Acta Psychiatrica Scandinavica, 203, 45—52.Google Scholar
Perris, C. (1971) Abnormality on paternal and maternal sides: observations in bipolar (manic-depressive) and unipolar depressive psychoses. British Journal of Psychiatry, 543, 207–10.Google Scholar
Perris, C. (1974) The heuristic value of a distinction between bipolar and unipolar affective disorders. In Classification and Prediction of Outcome of Depression (ed. Angst, J.), pp 75—97. Stuttgart and New York: F. K. Schattauer Verlag.Google Scholar
Puzynski, S. (1979) Depression. Warsaw: PZWL.Google Scholar
Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Annals of Human Genetics, 36, 163–84.Google Scholar
Shopsin, B., Mendlewicz, J., Suslak, L., Silbey, E. & Gershon, E. S. (1976) Genetics of affective disorders. II. Morbidity risks and genetic transmission. Neuropsychobiology, 2, 28—36.Google Scholar
Smeraldi, E., Negri, F. & Melica, A. M. (1977) A genetic study of affective disorders. Acta Psychiatrica Scandinavica, 56, 382–98.Google Scholar
Smith, C. (1976) Statistical resolution of genetic heterogeneity in familial disease. Annals of Human Genetics, 39, 281–91.CrossRefGoogle ScholarPubMed
Winokur, G., Clayton, P. J. & Reich, T. (1969) Manic Depressive Illness. St Louis: C. V. Mosby Company.Google Scholar
Winokur, G., Cadoret, R., Dorzab, J. & Baker, M. (1971) Depressive disease. A genetic study. Archives of General Psychiatry, 24, 135–44.Google Scholar
Winokur, G., (1972) Types of depressive illness. British Journal of Psychiatry, 120, 265–6.Google Scholar
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