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Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations

Published online by Cambridge University Press:  29 January 2018

Lionel Corbett ,
Samuel T. Christian ,
Richard D. Morin ,
Frederick Benington  and
John R. Smythies
Lionel Corbett
Affiliation:
Laboratory of Biological Psychiatry, Illinois State Psychiatric Institute, Chicago, Illinois 60612
Samuel T. Christian
Affiliation:
Neurosciences Program and Department of Psychiatry, University of Alabama, University Station Birmingham, Alabama 35294
Richard D. Morin
Affiliation:
Neurosciences Program and Department of Psychiatry, University of Alabama, University Station Birmingham, Alabama 35294
Frederick Benington
Affiliation:
Neurosciences Program and Department of Psychiatry, University of Alabama, University Station Birmingham, Alabama 35294
John R. Smythies
Affiliation:
Neurosciences Program and Department of Psychiatry, University of Alabama, University Station Birmingham, Alabama 35294
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Abstract

The incidence and quantities of dimethyltryptamine and O-methyl-bufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level.

Type
Papers
Information
The British Journal of Psychiatry , Volume 132 , Issue 2 , February 1978 , pp. 139 - 144
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Angrist, B., Gershon, S., Sathananthan, G., Walker, R. W., Lopez-Ramos, B., Mandel, L. R. & Vanden Heuvel, W. J. A. (1976) Dimethyltryptamine levels in blood of schizophrenic patients and control subjects. Psychopharmacologia, 47, 29–32.CrossRefGoogle ScholarPubMed
Benington, F., Morin, R. D. & Clark, L. C. (1965) 5-Methoxy-N-N-Dimethyltryptamine: a possible endogenous psychotoxin. Alabama Journal of Medical Science. 2, 397–403.Google Scholar
Benington, F., Christian, S. T. & Morin, R. D. (1975) Identification and separation of indolealkylamines by gas-liquid chromatographic analysis of their heptafluorobutyryl derivatives. Journal of Chromatography, 106, 435–9.Google Scholar
Carpenter, W. T., Strauss, J. S. & Batko, J. J. (1973) Flexible system for the diagnosis of schizophrenia: Report from the WHO International Pilot Study of Schizophrenia. Science, 182, 1275–8.Google Scholar
Christian, S. T., Benington, F., Morin, R. D. and Corbett, L. (1976) Gas-liquid chromatographi separation and identification of biologically importan indolealkylamines from human cerebrospinal fluid Biochemical Medicine, 14, 191–200.Google Scholar
Christian, S. T. Harrison, R. & Pagel, J. (1976) Evidence of dimethyltryptamine as naturally occurring transmitter in mammalian brain. Alabama Journal Medical Science, 13(2), 162–5.Google Scholar
Feighner, J. P., Robins, E. & Guze, S. G. (1972) Diagonostic criteria for use in psychiatric research. Archiv of General Psychiatry, 26, 56–63.CrossRefGoogle Scholar
Holmstedt, B. & Lindgren, J. E. (1967) In Ethn pharmacologic Search for Psychoactive Drugs (ed. Efron, D. H). Washington: United States Public Health Service.Google Scholar
Lipinski, J. F., Mandel, L. R., Alun, H. S., Vande Heuvel, W. J. A. & Walker, R. W. (1974) Blood dimethyltryptamine concentrations in psychoti disorders. Biological Psychiatry, 9, 89–91.Google ScholarPubMed
Mandel, L. R. & Walker, R. W. (1975) The bic synthesis of 5-Methoxy, N-N-Dimethyltryptamine i vitro. Life Sciences, 15, 1457–63.Google Scholar
Mandell, A. J. & Segal, D. S. (1973) The psychobiology of dopamine and the methylated indoleamines with particular reference to psychiatry. In Biologic Psychiatry (ed. Mendels, J.). Wiley.Google Scholar
Serban, M. D. & Gidynski, C. B. (1975) Differentiating criteria for acute-chronic distinction in schiz phrenia. Archives of General Psychiatry, 32, 705–12.Google Scholar
Wyatt, R. J., Mandel, L. D., Alun, H. S., Walke, R. W. & Vanden Heuvel, W. J. A. (1973) Ga chromatographic-mass spectromctric isotope dilution determination of N-N-dimethyltryptamine concentrations in normals and psychiatric patients. Psych pharmacologia, 31, 265–70.Google Scholar
Wyatt, R. J., Gillin, J. C., Kaplan, J., Stillman, R., Mandel, L. Alun, H. S., Vanden Heuvel, W. J. A. & Walke, R. W. (1974) N-N-Dimethyltryptamine—a possible relationship to schizophrenia? In Advances Bio-chemical Psychopharmacology. New York: Raven Press Google Scholar
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