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Grey matter correlates of syndromes in schizophrenia

A semi-automated analysis of structural magnetic resonance images

Published online by Cambridge University Press:  03 January 2018

S. E. Chua ,
I. C. Wright ,
J.-B. Poline ,
P. F. Liddle ,
R. M. Murray ,
R. S. J. Frackowiak ,
K. J. Friston  and
P. K. McGuire
S. E. Chua*
Affiliation:
Institute of Psychiatry, De Crespigny Park, London, and Castle Peak Hospital, Tuen Mun, Hong Kong
I. C. Wright
Affiliation:
Institute of Psychiatry, De Crespigny Park, London
J.-B. Poline
Affiliation:
Wellcome Department of Cognitive Neurology, National Hospital for Neurology and Neurosurgery, London
P. F. Liddle
Affiliation:
University of British Columbia, Vancouver BC, Canada
R. M. Murray
Affiliation:
Institute of Psychiatry, De Crespigny Park, London
R. S. J. Frackowiak
Affiliation:
Wellcome Department of Cognitive Neurology, National Hospital for Neurology and Neurosurgery, London
K. J. Friston
Affiliation:
Wellcome Department of Cognitive Neurology, National Hospital for Neurology and Neurosurgery, London
P. K. McGuire
Affiliation:
Institute of Psychiatry, De Crespigny Park, London
*
Dr S. E. Chua, Department of Psychiatry, Queen Mary Hospital, Pokfulam Road, Hong Kong
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Abstract

Background

Symptoms in schizophrenia duster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes.

Method

A semi-automated method was used to examine structural magnetic resonance images in 12 patients with schizophrenia. The relationship between the relative regional grey matter volume and ratings of the syndromes of psychomotor poverty, disorganisation and reality distortion was investigated.

Results

There was a significant negative correlation between psychomotor poverty score and the relative volume of the left ventro-medial prefrontal grey matter, and a significant positive correlation between disorganisation and the relative volumes of the hippocampus, and the parahippocampal/fusiform gyrus bilaterally.

Conclusion

The correlation between psychomotor poverty and left prefrontal grey matter volume resembles that previously seen with prefrontal blood flow in the same patients, suggesting that this functional abnormality is related to an underlying anatomical change.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 5 , May 1997 , pp. 406 - 410
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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