Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-05T04:17:37.815Z Has data issue: false hasContentIssue false

Glucose Metabolism in Unipolar Depression

Published online by Cambridge University Press:  29 January 2018

J. H. Wright
Affiliation:
Neuropsychiatric Institute, University of Michigan, Ann Arbor, Michigan
J. J. Jacisin
Affiliation:
Neuropsychiatric Institute, University of Michigan, Ann Arbor, Michigan
N. S. Radin
Affiliation:
Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan
R. A. Bell
Affiliation:
University of Louisville School of Medicine, Louisville, Kentucky

Summary

Glucose utilization, serum insulin, human growth hormone, and free fatty acids were studied in 18 unipolar depressed patients and 14 normal controls, using the intravenous glucose tolerance test. Patients were kept drug-free for at least two weeks before testing, and physical activity and diet were carefully controlled. Previously described abnormalities in the balance between glucose and free fatty adds were not seen, but endogenous depression was associated with lowered glucose utilization rate with insulin resistance. Changes in kinetics of membrane transport in endogenous depression which could account for this finding are discussed.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists, 1978 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boden, G. & Soeldner, J. S. (1967) A sensitive double antibody radio-immunoassay for human growth hormone (HGH): levels of serum HGH following rapid tolbutamide infusion. Diabetologia, 3, 413–21.CrossRefGoogle Scholar
Carroll, B. J., Curtis, G. C. & Mendels, J. (1976) Neuroendocrine regulation in depression. Archives of General Psychiatry, 33, 1039–44.Google Scholar
Coppen, A. (1976) Cortisol levels in depression. Postgraduate Medical Journal, 52, 116–18.Google Scholar
Dole, V. P. (1956) A relation between non-esterified fatty acids in plasma and the metabolism of glucose. Journal of Clinical Investigation, 35, 150–54.Google Scholar
Dole, V. P. & Meinertz, H. (1960) Microdetermination of long-chain fatty acids in plasma and tissues. Journal of Biological Chemistry, 235, 2595–99.Google Scholar
Gordon, R. S. & Cherkes, A. (1956) Unesterified fatty acids in human blood plasma. Journal of Clinical Investigation, 35, 206–12.Google Scholar
Gruen, P. H., Sachar, E. J., Altman, N. & Sassin, J. (1975) Growth hormone responses to hypoglycemia in postmenopausal depressed women. Archives of General Psychiatry, 32, 3133.Google Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–96.Google Scholar
Heninger, G. R., Mueller, P. S. & Davis, L. S. (1975) Depressive symptoms and the glucose tolerance test and the insulin tolerance test. Journal of Nervous and Mental Disease, 161, 421–32.Google Scholar
Herzberg, B., Coppen, A. & Marks, V. (1968) Glucose tolerance in depression. British Journal of Psychiatry, 114, 627–30.Google Scholar
Kahn, C. R., Flier, J. S., Bar, R. S., Archer, J. A., Gordon, P., Martin, M. M. & Roth, J. (1976) The syndromes of insulin resistance and acanthosis nigricans. New England Journal of Medicine, 294, 739–45.Google Scholar
Lancer, G., Heinze, G., Rein, B. & Matussek, N. (1976) Reduced growth hormone responses to amphetamine in ‘endogenous’ depressive patients. Archives of General Psychiatry, 33, 1471–75.Google Scholar
McCowan, P. K. & Quastel, J. H. (1931) Blood sugar studies in abnormal mental states. Journal of Mental Science, 77, 525548.Google Scholar
Martin, D. B. (1976) Insulin resistance: new insights. New England Journal of Medicine, 294, 778–79.CrossRefGoogle ScholarPubMed
Mendels, J. (1968) Depression: the distinction between syndrome and symptom. British Journal of Psychiatry, 114, 1549–54.Google Scholar
Mendels, J. & Cochrane, C. (1968) The nosology of depression: the endogenous-reactive concept. American Journal of Psychiatry, 124, 111.Google Scholar
Mueller, P. S., Heninger, G. R. & McDonald, R. K. (1969) Intravenous glucose tolerance test in depression. Archives of General Psychiatry, 21, 470–77.Google ScholarPubMed
Mueller, P. S., Davis, J. M., Bunney, W. E., Weil-Mallerbe, H. & Cardon, P. V. (1970) Plasma free fatty acids concentration in depressive illness. Archives of General Psychiatry, 22, 216–21.Google Scholar
Mueller, P. S., Heninger, G. R. & McDonald, R. K. (1969) Insulin tolerance test in depression. Archives of General Psychiatry, 21, 587–94.Google ScholarPubMed
Murphy, H. B. M., Wittkower, E. D. & Chance, N. A. (1964) Cross cultural inquiry into the symptomatology of depression. Transcultural Psychiatric Research Review, 1, 518.Google Scholar
Myant, N. B. (1970) Lipid metabolism. In: Scientific Foundations of Obstetrics and Gynaecology (ed. Philipp, E. E.). F. A. Davis Company.Google Scholar
Pennick, S. B., Pearson, N. & Silverman, A. J. (1970) Free fatty acids in depression. In: Science and Psychoanalysis (ed. Masserman, J. H.). Volume XVII, Grune and Stratum, Inc. Google Scholar
Pryce, I. G. (1958) The relationship between glucose tolerance, body weight, and clinical state in melancholia. Journal of Mental Science, 104, (437), 1079–92.Google Scholar
Pryce, I. G. (1964) The relationship between 17-hydroxycorticosteroid excretion and glucose utilization in depressions. British Journal of Psychiatry, 110, 9094.CrossRefGoogle ScholarPubMed
Radin, N. S. (1977) Modification of the dole method of free fatty acid determination. Unpublished manuscript. Details available upon request.Google Scholar
Soeldner, J. S. (Slone, D. (1965) Critical variables in the radio-immunoassay of serum insulin using the double antibody technic. Diabetes, 14, 771–9.Google Scholar
VanPraag, H. M. & Leijnse, B. (1965) Depression, glucose tolerance, peripheral glucose uptake and their alterations under the influence of anti-depressive drugs of the hydrazine type. Psychopharmacologia (Berlin), 8, 6778.Google Scholar
VanPraag, H. M. & Leijnse, B. (1966) Some aspects of the metabolism of glucose and of the non-esterified fatty acids in depressive patients. Psychopharmacologia (Berlin), 9, 220–33.Google Scholar
Zung, W. W. K. (1965) A self-rating depression scale. Archives of General Psychiatry, 12, 6370.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.