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The ‘glucocorticoid cascade’ hypothesis in man

Prolonged stress may cause permanent brain damage

Published online by Cambridge University Press:  03 January 2018

John T. O'Brien*
Affiliation:
Department of Psychiatry and Institute for the Health of the Elderly, University of Newcastle
*
Dr John O'Brien, Castle side Unit, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE. Fax: 01912195040
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Abstract

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Type
Editorials
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

References

Abas, M. A., Sahaldan, B. J. & Levy, R. (1990) Neuropsychological deficits and CT scan changes in elderly depressives. Psychological Medicine. 20, 507520.Google Scholar
Axelson, D. A., Doralswamy, P. M., McDonald, W. M., et al (1993) Hypercortisolaemia and hippocampal changes in depression. Psychiatry Research, 47, 163173.Google Scholar
Bremner, J. D., Randall, P., Scott, T. M., et al (1995) MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. American Journal of Psychiatry, 152, 973981.Google Scholar
Brooke, S. M., Haas-Johnson, A. M., Kaplan, J. R., et al (1994) Dexamethasone resistance among nonhuman primates associated with a selective decrease of glucocorticoid receptors in the hippocampus and a history of social instability. Neuroendocnnology, 60, 134140.CrossRefGoogle Scholar
Coffey, C. E., Wilkinson, W. C., Weiner, R., et al (1993) The dexamethasone suppression test and quantitative cerebral anatomy in depression. Biological Psychiatry. 33, 442449.Google Scholar
Dinan, T. G. (1994) Glucocorticoids and the genesis of depressive illness. British Journal of Psychiatry, 164, 365371.CrossRefGoogle ScholarPubMed
Ferrier, I. N., Lister, E. S., Rjordan, D. M., et al (1991) A follow-up study of elderly depressives and Alzheimer-type dementia. Relationship with DST status. International Journal of Geriatric Psychiatry, 6, 279286.CrossRefGoogle Scholar
Golomb, J., De Leon, M., Kluger, A., et al (1993) Hippocampal atrophy in normal ageing, an association with recent memory impairment. Archives of Neurology, 50, 967973.Google Scholar
Heuser, I. J., Gotthardt, U., Schweiger, U., et al (1994) Age-associated changes of pituitary-adrenocorticol hormone regulations in humans: importance of gender. Neurobiology of Ageing. 15, 227231.Google Scholar
Jacobson, L. & Sapolsky, R. (1991) The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocrine Reviews. 12. 118 134.Google Scholar
Landfield, P. W., Baskin, R. K. & Pitier, T. A. (1981) Brain aging correlates: retardation by hormonal-pharmacological treatments. Science. 214, 581584.Google Scholar
Landfield, P. W., Baskin, R. K. & Pitier, T. A. & Eldridge, J. C. (1994) Evolving aspects of the glucocorticoid hypothesis of brain aging: hormonal modulation of neuronal calcium homeostasis. Neurobiology of Aging, 15, 579588.CrossRefGoogle ScholarPubMed
Levy, A., Dachir, S., Arbel, I., et al (1994) Aging stress and cognitive function. Annals of the New York Academy of Sciences. 717, 7988.CrossRefGoogle ScholarPubMed
Lupien, S., Lecours, A. R., Lussier, I., et al (1994) Basal cortisol levels and cognitive decline in human aging. Journal of Neuroscience, 14, 28932903.CrossRefGoogle ScholarPubMed
Mauri, M., Sinforiani, E., Bono, G., et al (1993) Memory impairment in Cushings disease. Acta Neurologica Scandmavica. 87, 5255.Google Scholar
Meaney, M. J., Aitken, D. H., Van Berkel, C., et al (1981) Effect of neonatal handling on age-related impairments associated with the hippocampus. Science. 239, 766768.Google Scholar
Mitchell, A. J. (1995) The contribution of hypercortisolaemia to the cognitive decline of geriatric depression. International Journal of Geriatric Psychiatry, 10, 401409.Google Scholar
Newcomer, J. W., Craft, S., Hershey, T., et al (1994) Glucocorticoid-induced impairment in declarative memory performance in adult humans. Journal of Neurosciene. 14, 20472053.Google Scholar
O'Brien, J. T., Schweitzer, I., Ames, D., et al (1994) Cortisol suppression by dexamethasone in the healthy elderly: effects of age. dexamethasone levels and cognitive function. Biological Psychiatry, 36, 389394.CrossRefGoogle ScholarPubMed
O'Brien, J. T., Schweitzer, I., Desmond, P., Ames, D., et al (1996) Clinical and magnetic resonance imaging correlates of hypothalmic-pituitary-adrenal axis function in depression and Alzheimer's disease. British Journal of Psychiatry, 168, 679687.CrossRefGoogle Scholar
O'Donnell, D., Larocque, S., Seckl, J. R., et al (1994) Postnatal handling alters glucocorticoid but not mineralocorticoid messenger RNA expression in the hippocampus of adult rats. Molecular Brain Research. 26, 242248.CrossRefGoogle Scholar
Orrell, M. W. & O'Dwyer, A. M. (1995) Dementia, ageing and the stress control system. Lancet. 345, 666667.Google Scholar
Raadsheer, F. C., Oorschot, D. E., Verwer, R. W. H., et al (1994) Age-related increase in the total number of corticotropin-releasing hormone neurons in the human paraventricular nucleus in controls and Alzheimer's disease: comparison of the dissector with an unfolding method. Journal of Comparative Neurology. 339, 447457.Google Scholar
Sapolsky, R. M., Krey, L. C. & McEwen, B. (1986) The neuroendocnnology of stress and aging: The glucocorticoid cascade hypothesis. Endocrine Reviews. 7, 284301.Google Scholar
Sapolsky, R. M., Krey, L. C., McEwen, B. & Plotsky, P. M. (1990) Hypercortisolism and its possible neural bases. Biological Psychiatry, 27, 937952.Google Scholar
Sharma, R. P., Pandey, G. N., Janicak, P. G., et al (1988) The effect of diagnosis and age on the DST: a meta-analytic approach. Biological Psychiatry. 24, 555568.Google Scholar
Seckl, J. R. & Olsson, T. (1995) Glucocorticoid hypersecretion and the age-impaired hippocampus: cause or effect. Journal of Endocrinology, 145, 201211.Google Scholar
Starkman, M. N., Gebarski, S. S., Berent, S., et al (1992) Hippocampal formation volume, memory dysfunction and cortisol levels in patients with Cushing's syndrome. Biological Psychiatry, 32, 756765.Google Scholar
Uno, H., Tarara, R., Else, J. E., et al (1989) Hippocampal damage associated with prolonged and fatal stress in primates. Journal of Neuroscience. 9, 17051711.CrossRefGoogle ScholarPubMed
Welner, M. F., Vobach, S., Svetlik, D., et al (1993) Cortisol secretion and Alzheimer's disease progression – A preliminary report. Biological Psychiatry, 34, 158163.Google Scholar
Wetzel, D. M., Bohn, M. C., Kazee, A. M., et al (1995) Glucocorticoid receptor mRNA in Alzheimer's diseased hippocampus. Brain Research, 679, 7281.Google Scholar
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