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Genetics of novel therapeutic targets in schizophrenia

Published online by Cambridge University Press:  06 August 2018

R. Kerwin  and
M. Owen
R. Kerwin*
Affiliation:
Institute of Psychiatry, London
M. Owen
Affiliation:
University of Wales College of Medicine
*
Correspondence: Professor R. Kerwin, Institute of Psychiatry, Section of Clinical Neuropharmacology, De Crespigny Park, London SE5 8AF
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Extract

For many years, following the introduction of chlorpromazine in the 1950s, little progress was made in the discovery of new drugs for schizophrenia (Reynolds, 1992). Dopamine D2 receptor blockade was recognised as the only therapeutic target for antipsychotics (Creese et al, 1976) and the inevitable consequences of striatal blockade remained problematic. However, the strategies and stimuli for discovery of new drugs changed with the introduction of new, atypical antipsychotics in the 1990s. These include clozapine, remoxipride (now withdrawn), olanzapine, risperidone and sertindole (Kerwin & Taylor, 1996). The goal of antipsychotic drug development has always been to widen the therapeutic ratio between efficacy and adverse effects. These new drugs have in the main achieved this. However, which therapeutic targets these drugs employ remains a mystery, and this information is clearly important for future research into more selectively targeted agents.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 174 , Issue S38: New antipsychotics - preclinical and clinical comparisons , May 1999 , pp. 1 - 4
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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