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Genetical Analysis of Unipolar and Bipolar Endogenous Affective Psychoses

Published online by Cambridge University Press:  29 January 2018

Olga Trzebiatowska-Trzeciak
Olga Trzebiatowska-Trzeciak*
Affiliation:
Psychiatric Out-patients Department, Szamotuly, Poland
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Abstract

The mode of inheritance of affective psychoses was studied in 800 first degree and 582 second degree relatives of 122 probands. Morbidity risk for unipolar depression was 12·0±3·2 and 11·4±2·7 per cent respectively for parents and siblings of probands suffering from unipolar depression. Morbidity risk for manic-depressive psychosis for the respective groups of first degree relatives of manic-depressive probands was 15·1±3·2 and 16·9±3·2 per cent. In second degree relatives the morbidity risk was 3·4±1·0 and 5·3±1·4 per cent for unipolar depression and manic-depressive psychosis respectively.

The results indicate the role of genetical factors in the etiology of both types of affective disorder and show that unipolar depression and manic-depressive psychosis are distinct entities. The hypothesis of X-linked dominant transmission was not confirmed in either of these affective disorders. By means of the computational model of Slater, no results compatible with a polygenic inheritance of unipolar depression or manic-depressive psychosis were found.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 131 , Issue 5 , November 1977 , pp. 478 - 485
Copyright
Copyright © Royal College of Psychiatrists, 1977 

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