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Genetic Theorizing and Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Irving I. Gottesman  and
James Shields
Irving I. Gottesman
Affiliation:
Departments of Psychology and Psychiatry and Genetics Graduate Faculty, Elliott Hall, University of Minnesota, Minneapolis, Minn. 55455, U.S.A.
James Shields
Affiliation:
Institute of Psychiatry, De Crespigny Park, London, SE5 8 AF
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Extract

Schizophrenia research embodies a microcosm of the vexing problems that confront the behavioural sciences, but particularly those disciplines concerned with psychopathology. We are ignorant of the means to prevent schizophrenia because we continue to be ignorant about its aetiology. Despite recognizable descriptions of the syndrome in ancient Hindu treatises (c. 1400 b.c.) and 76 years after its designation as dementia praecox by Kraepelin (1896), we are still grappling with such basic issues as when and how to diagnose Eugen Bleuler's (1911) ‘group of schizophrenias' (cf. Katz, Cole, and Barton, 1968). Despite brilliant advances in molecular biology, neurochemistry, and brain-behaviour phenomena generally, we cannot pinpoint any necessary biological defect in all or most schizophrenics. Despite selfless expenditures of time and energy by gifted psychotherapists and sophisticated social science efforts, we cannot specify any necessary life experience, either at the level of the family or of a culture, common to all or most schizophrenics. While there is obvious merit in casting the problem in an interactionist framework, aetiology still defies an easy solution because we must then isolate what element(s) in the genotype interact with what element(s) in the internal and/or external environment (as well as when and how) to produce the phenotype we recognize as a schizophrenic one.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 122 , Issue 566 , January 1973 , pp. 15 - 30
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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