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A Genetic Model of Narcolepsy

Published online by Cambridge University Press:  29 January 2018

James F. Leckman  and
Elliot S. Gershon
James F. Leckman
Affiliation:
Unit on Clinical Psychogenetics, Adult Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm. 3N218, 9000 Rockville Pike, Bethesda, Maryland 20014
Elliot S. Gershon
Affiliation:
Unit on Clinical Psychogenetics, Adult Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm. 3N218, 9000 Rockville Pike, Bethesda, Maryland 20014
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Summary

An analysis of recently published family history data on rapid eye movement (REM) narcolepsy was undertaken to determine the goodness-of-fit of a multifactorial (MF) model of inheritance. The analysis revealed that a two-threshold MF model can successfully account for the prevalence of REM narcolepsy and other disorders of excessive sleep (DES) observed in the first-degree relatives of the REM narcoleptic probands studied.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 3 , March 1976 , pp. 276 - 279
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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References

Bruhova, S. & Roth, B. (1972) Heredofamilial aspects of narcolepsy and hypersomnia. Archives Suisses di Neurologie Neurochirurgie et Psychiatrie, 110, 45—54.Google Scholar
Daly, D. D. & Yoss, R. E. (1959) A family with narcolepsy. Proceedings of the Staff Meetings of the Mayo Clinic, 34, 313—20.Google ScholarPubMed
Falconer, D. S. (1965) The inheritance of liability to certain diseases, estimated from the incidence among relatives. Annals of Human Genetics, 29, 51—76.CrossRefGoogle Scholar
Guillemnault, C., Carskadon, M. & Dement, W. C. (1974) On the treatment of rapid eye movement narcolepsy. Archives of Neurology, 30, 90—3.Google Scholar
Imlah, N. W. (1961) Narcolepsy in identical twins. Journal of Neurology, Neurosurgery and Psychiatry, 24, 158—60.CrossRefGoogle ScholarPubMed
Kessler, S., Guilleminault, C. & Dement, W. C. (1974) A family study of 50 REM narcoleptics. Acta Neurologica Scandinavica, 50, 503—12.Google ScholarPubMed
Krabbe, E. & Magnussen, G. (1942) On narcolepsy: I. Familial narcolepsy. Acta Psychiatrica Neurologica, 17, 149—73.CrossRefGoogle Scholar
Morton, N. E. & Maclean, C. J. (1974) Analysis of family resemblance. III. Complex segregation of quantitative traits. American Journal of Human Genetics, 26, 489—503.Google Scholar
Rechtschaffen, A., Wolpert, E. A., Dement, W. C., Mitchell, S. A. & Fisher, C. (1963) Nocturnal sleep of narcoleptics. Electroencephalography and Clinical Neurophysiology, 15, 599—609.CrossRefGoogle ScholarPubMed
Reich, T., Cloninger, C. R. & Guze, S. B. (1975) The multifactorial model of disease transmission. British Journal of Psychiatry, 127, 1—23.CrossRefGoogle ScholarPubMed
Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Annals of Human Genetics, 36, 163—84.CrossRefGoogle ScholarPubMed
Roth, B., Bruhova, S. & Lehovsky, M. (1969) REM sleep and NREM sleep in narcolepsy and hypersomnia. Electroencephalography and Clinical Neurophysiology, 26, 176—82.CrossRefGoogle ScholarPubMed
Sours, J. A. (1963) Narcolepsy and other disturbances in the sleep-waking rhythm, a study of 115 cases and a review of the literature. Journal of Nervous and Mental Diseases, 137, 525—42.CrossRefGoogle Scholar
Strömgren, E. (1935) Zum Ersatz des Weinbergschen ‘abgekurzten Verfahrens’. Zeitschrift für die gesamte Neurologie und Psychiatrie, 153, 784—97.CrossRefGoogle Scholar
Yoss, R. E. & Daly, D. D. (1960) Narcolepsy. Medical Clinics of North America, 44, 953—68CrossRefGoogle ScholarPubMed
Yoss, R. E. (1975) The inheritance of diurnal sleepiness as measured by pupillography. Mayo Clinic Proceedings, 45, 426—37Google Scholar
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