Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-22T16:09:47.699Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic anticipation and imprinting in bipolar I illness

Published online by Cambridge University Press:  03 January 2018

Maria Grigoroiu-Serbanescu ,
Pryia J. Wickramaratne ,
Susan E. Hodge ,
Stefan Milea  and
Radu Mihailescu
Maria Grigoroiu-Serbanescu*
Affiliation:
Psychiatric Research Laboratory, The ‘Gh. Marinescu’ Psychiatric Hospital
Pryia J. Wickramaratne
Affiliation:
Columbia University, New York State Psychiatric Institute, Department of Genetic Epidemiology
Susan E. Hodge
Affiliation:
Columbia University, New York State Psychiatric Institute, Department of Genetic Epidemiology
Stefan Milea
Affiliation:
Psychiatric Hospital, Bucharest
Radu Mihailescu
Affiliation:
Psychiatric Hospital, Bucharest
*
Dr Maria Grigoroiu-Serbanescu, The Psychiatric Research Laboratory, The ‘Gh. Marinescu’ Psychiatric Hospital, Sos. Berceni, 10, O. P.8, R-75622 Bucharest, Romania
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The study focused on: (1) the existence of genetic anticipation in a randomly selected sample of bipolar I patients using broad and narrow definitions of the affection status in the parental generation; (2) the relationship between anticipation and the age at investigation in probands and in their relatives; (3) the relationship between anticipation and imprinting.

Method

One hundred and fifteen bipolar I patients and their first- to third-degree relatives were diagnosed according to DSM–III–R criteria using the Diagnostic Interview for Genetic Studies and the Family Interview for Genetic Studies.

Results

Age at onset was found to be 6–10 years younger in probands with affected parents or uncles/aunts. Two-thirds of these families showed positive anticipation under both the broad and the narrow definitions of affection status in the parents' generation. The age at investigation was younger in probands showing positive anticipation. Anticipation was found only in probands inheriting the disorder from the paternal side.

Conclusions

In spite of the inevitable association between young current age and young age at onset, which could result in spurious anticipation effects, our findings suggest that this phenomenon is not the sole cause of observed anticipation.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 2 , February 1997 , pp. 162 - 166
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn. revised) (DSM-III-R). Washington, DC: APA.Google Scholar
Duyao, M., Ambrose, C., Myers, R., et al (1993) Trinucleotide repeat length instability and age of onset in Huntington disease. Nature Genetics, 4, 387–392.CrossRefGoogle Scholar
Gelernter, J. (1995) Genetics of bipolar affective disorder: time for another reinvention? American Journal of Human Genetics, 56, 1262–1266.Google ScholarPubMed
Hodge, S. E. & Wickramaratne, P. J. (1995) Statistical pitfalls in detecting age-of-onset anticipation and detecting ascertainment bias. Psychiatric Genetics, 5, 43–47.Google Scholar
Howland, R. H. & Thase, M. E. (1993) A comprehensive review of cyclothymic disorder. Journal of Nervous and Mental Disease, 181, 485–493.Google Scholar
McInnis, M. G., McMahon, F. J., Chase, G. A., et al (1993) Anticipation in bipolar affective disorder American Journal of Human Genetics, 53, 385–390.Google ScholarPubMed
McMahon, F. J., Colin Stine, O., Meyers, D. A., et al (1995) Patterns of maternal transmission in bipolar affective disorder American Journal of Human Genetics, 56, 1277–1286.Google Scholar
Nylander, P. O., Engstrüm, C., Chotai, J., et al (1994) Anticipation in Swedish families with bipolar affective disorder. Journal of Medical Genetics, 31, 686–689.CrossRefGoogle ScholarPubMed
Oberie, I., Rousseeu, R. & Heltz, D. (1991) Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science. 262, 1097–1102.Google Scholar
Penrose, L. S. (1948) The problem of anticipation in pedigrees of dystrophia myotonica. Annals of Eugenics, 14, 125–132.CrossRefGoogle ScholarPubMed
Petronis, A. & Kennedy, J. L. (1995) Unstable genes -unstable mind? American Journal of Psychiatry, 152, 164–172.Google Scholar
Petronis, A. & Kennedy, J. L., Sherrington, R. & Kennedy, J. L. (1994) Regression to the mean does not exclude anticipation and unstable DNA disease. American Journal of Human Genetics, 55, 589–590.Google Scholar
Serbanescu-Grigoroiu, M., Nüthen, M., Propping, P., et al (1995) Clinical evidence of genomic imprinting in bipolar I disorder Acta Psychiatrica Scandinavica, 92, 365–370.Google Scholar
Spitzer, R. L., Williams, J. B. W. & Gibbon, M. (1987) Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II), New York: New York State Psychiatric Institute.Google Scholar
Verkerk, A. J. M. H., Pieratti, M., Sutcliffe, J. S., et al (1991) Identification of a gene (FRM-I) containing a COG repeat coincident with a breakpoint cluster region of exhibiting length variation in fragile X syndrome. Cell, 65, 905–914.CrossRefGoogle Scholar
Wiessman, M. M., Merikangas, K. Wickramaratne, P. J. et al (1986) Understanding the clinical heterogeneity of major depression using family data. Archives of General Psychiatry, 431 430–434.CrossRefGoogle Scholar
Winokur, G., Coryell, W., Keller, M., et al (1995) A family study of manic-depressive (bipolar I) disease. Archives of General Psychiatry, 52, 367–373.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.