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Gastric Emptying, Body Weight and Symptoms in Primary Anorexia Nervosa

Long-Term Effects of Cisapride

Published online by Cambridge University Press:  02 January 2018

Georg Stacher ,
Thalia-Anthi Abatzi-Wenzel ,
Stefan Wiesnagrotzki ,
Helmar Bergmann ,
Christa Schneider  and
Gabriele Gaupmann
Georg Stacher*
Affiliation:
Departments of Psychiatry and Surgery I
Thalia-Anthi Abatzi-Wenzel
Affiliation:
Division of Psychosomatic Medicine, Department of Psychiatry
Stefan Wiesnagrotzki
Affiliation:
Division of Psychosomatic Medicine, Department of Psychiatry
Helmar Bergmann
Affiliation:
Departments of Psychiatry and Surgery I
Christa Schneider
Affiliation:
Division of Psychosomatic Medicine, Department of Psychiatry
Gabriele Gaupmann
Affiliation:
Department of Biomedical Engineering and Physics, University of Vienna
*
∗Psychophysiology Unit, Wahringer Gürtel 18–20, A-1090 Wien, Austria
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Abstract

In a double-blind trial, 12 out-patients with primary anorexia nervosa received, for six weeks, either 10 mg cisapride or placebo, three times a day. Cisapride accelerated gastric emptying of a radiolabelled semisolid meal in all six patients; five gained weight and symptoms of gastric retention ameliorated in four. With placebo, three of six had emptying enhanced, four gained weight, and one's symptoms improved. For another six weeks, all patients received cisapride. In five of the patients who had received cisapride, emptying further accelerated or remained stable; in one it slowed. Of the six patients who received placebo, four had emptying accelerated, five gained weight, and symptoms improved in four. Longer administration of cisapride may, by enhancing gastric motor activity, alleviate symptoms of retention and thus help to change eating behaviour.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 162 , Issue 3 , March 1993 , pp. 398 - 402
Copyright
Copyright © The Royal College of Psychiatrists 

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