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Functional Tests of the Corpus Callosum in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Gareth H. Jones  and
Julian J. Miller
Gareth H. Jones
Affiliation:
Department of Psychological Medicine, Welsh National School of Medicine, Whitchurch Hospital, Cardiff CF4 7XB
Julian J. Miller
Affiliation:
M.R.C. Institute of Hearing Research, (Welsh Section), University Hospital of Wales, Heath Park, Cardiff CF4 4XN
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Summary

The corpus callosum, a cerebral commissure of 200,000,000 fibres, is thickened in chronic schizophrenia and several neuropsychological and neurophysiological techniques have suggested poor links between the two cerebral hemispheres. The interhemispheric conduction time across the corpus callosum, measured in 12 schizophrenics, using the ipsilateral/contralateral latency differences of the early somatosensory evoked response, was found to be effectively zero. It is suggested that schizophrenia is a split-brain condition akin to agenesis of the corpus callosum, unrecognized through the use of compensatory ipsilateral sensory pathways.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 139 , Issue 6 , December 1981 , pp. 553 - 557
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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References

Beaumont, J. G. & Dimond, S. J. (1973) Brain disconnection and schizophrenia. British Journal of Psychiatry, 123, 661–2.CrossRefGoogle ScholarPubMed
Crow, T. J. (1980) Molecular pathology of schizophrenia; more than one disease process? British Medical Journal, 280, 66–8.Google Scholar
Duff, T. A. (1980) Topography of scalp recorded potentials evoked by stimulation of the digits. Electroencelphalography and Clinical Neurophysiology, 49, 452–60.Google Scholar
Fish, B. & Hagin, R. (1972) Visual-motor disorders in infants at risk for schizophrenia. Archives of General Psychiatry, 27, 594–8.Google Scholar
Flor-Henry, P. (1976) Lateralized temporal-limbic dysfunction and psychopathology. Annals of the New York Academy of Science, 280, 777–95.CrossRefGoogle ScholarPubMed
Garmezy, N. (1977) On some risks in at-risk research. Psychological Medicine, 7, 1—6.CrossRefGoogle Scholar
Gazzaniga, M. S., Risse, G. L., Springer, S. P., Clark, E. & Wilson, D. H. (1975) Psychologic and neurologic consequences of partial and complete cerebral commissurotomy. Neurology, 25, 10—15.Google Scholar
Green, P. (1978) Defective interhemispheric transfer in schizophrenia. Journal of Abnormal Psychology, 87, 472–80.Google Scholar
Green, P., Glass, A. & O'Callaghan, M. A. J. (1979) Some implications of abnormal hemisphere interaction in schizophrenia. In Hemisphere Asymmetries of Function in Psychopathology (eds. Gruzelier, J. and Flor-Henry, P.). Amsterdam: Elsevier/North Holland Biomedical Press.Google Scholar
Gruzelier, J. H. & Venables, P. H. (1974) Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: replication and evidence of lateral asymmetry in patients with depression and disorders of personality. Biological Psychiatry, 8, 55—73.Google ScholarPubMed
Hare, E. H. (1980) Seasonal variations in psychiatric illness. Trends in Neurosciences, 3 (12), 295–8.Google Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., Stevens, M., Kreel, L. & Husband, J. (1978) The dementia of dementia praecox. Acta Psychiatrica Scandinavica, 57, 305–24.CrossRefGoogle ScholarPubMed
Kendell, R. E. (1975) The Role of Diagnosis in Psychiatry, pp. 70–85. Oxford: Blackwell.Google Scholar
Liberson, W. T. (1966) Study of evoked potentials in aphasics. American Journal of Physical Medicine, 45, 135–42.CrossRefGoogle ScholarPubMed
Salamy, A. (1978) Commissural transmission: Maturational changes in humans. Science, 200, 1409–11.Google Scholar
Schneider, K. (1959) Clinical Psychopathology. English translation, 5th edition by Hamilton, M. W. New York: Grune and Stratton.Google Scholar
Sperry, R. W. (1968) Plasticity of neural maturation. Developmental Biology, Supplement 2, 306–27.Google Scholar
Sperry, R. W. (1971) How a developing brain gets itself properly wired for adaptive function. In The Biopsychology of Development (eds. Tobach, E., Aaronson, L. R. and Shaw, F.), pp 27—44. New York: Academic Press.Google Scholar
Robinson, D. L. (1973) Electrophysiological analysis of inter-hemispheric relations in the second somatosensory cortex of the cat. Experimental Brain Research, 18, 131–44.Google Scholar
Rosenthal, R. & Bigelow, L. B. (1972) Quantitative brain measurements in chronic schizophrenia. British Journal of Psychiatry, 121, 259–64.Google Scholar
Tress, K. H., Kugler, B. T. & Coudrey, D. J. (1979) Interhemispheric integration in schizophrenia. In Hemisphere Asymmetries of Function in Psychopathology, (eds. Gruzelier, J. and Flor-Henry, P.). Amsterdam: Elsevier/North Holland Biomedical Press.Google Scholar
Tyrell, D. A. J., Parry, R. P., Crow, T. J., Johnstone, E. & Ferrier, I. N. (1979) Possible virus in schizophrenia and some neurological disorders. Lancet, i, 839–41.Google Scholar
Woolsey, C. W. (1947) Patterns of sensory representation in the cerebral cortex. Federation Proceedings, 6, 437–41.Google Scholar
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