Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-31T14:46:49.187Z Has data issue: false hasContentIssue false
  • English
  • Français

Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)

Published online by Cambridge University Press:  02 January 2018

Nick Craddock ,
Mike Owen ,
Susan Burge ,
Bobby Kurian ,
Phil Thomas  and
Peter McGuffin
Nick Craddock*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
Mike Owen
Affiliation:
Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Cardiff CF4 4XN
Susan Burge
Affiliation:
Stoke Mandeville Hospital, Mandeville Road, Aylesbury, Bucks HP21 8AL
Bobby Kurian
Affiliation:
Ysbyty Gwynedd, Bangor, Gwynedd
Phil Thomas
Affiliation:
Meirionydd Mental Health Office, Bron Y Garth Hospital, Penrhyndeudraeth, Gwynedd LL48 6HD
Peter McGuffin
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

Darier's disease is a rare autosomal dominantly inherited keratosis. This is an account of one family in which there is co-occurrence of major affective disorder and Darier's disease in five members and absence of both disorders in five members. The pedigree is consistent with genetic linkage between the Darier gene and a major autosomal dominant susceptibility locus for major affective disorder. When the Darier's disease gene has been mapped, its chromosomal location will be an interesting candidate locus for linkage studies of major affective disorder.

Type
Peer Review
Information
The British Journal of Psychiatry , Volume 164 , Issue 3 , March 1994 , pp. 355 - 358
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington DC: APA.Google Scholar
Burge, S. M. (1989) Darier's disease, keratins and proteases: a review. Journal of the Royal Society of Medicine, 82, 673–676.Google Scholar
Burge, S. M. (1992) Hailey-Hailey disease: the clinical features, response to treatment and prognosis. British Journal of Dermatology, 126, 275–282.CrossRefGoogle ScholarPubMed
Burge, S. M., Millard, P. R. & Wojnarowska, F. (1991) Hailey-Hailey disease: a widespread abnormality of cell adhesion. British Journal of Dermatology, 124, 329–332.CrossRefGoogle ScholarPubMed
Burge, S. M., & Wilkinson, J. D. (1992) Darier–White disease: a review of the clinical features in 163 patients. Journal of the American Academy of Dermatology, 27, 40–50.CrossRefGoogle ScholarPubMed
Clark, R. D., Hammer, C. J. & Patterson, S. D. (1986) A cutaneous disorder (Darier's disease) evidently exacerbated by lithium carbonate. Psychosomatics, 27, 800–801.CrossRefGoogle ScholarPubMed
Denicoff, K. D., Lehman, Z. A., Rubinow, D. R., et al (1990) Suicidal ideation in Darier's disease. Journal of the American Academy of Dermatology, 22, 196–198.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview. The Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35, 837–844.CrossRefGoogle ScholarPubMed
Körner, J., Rietschel, M., Nöthen, M. M., et al (1993) Familial cosegration of affective disorder and Hailey-Hailey disease. British Journal of Psychiatry, 163, 109–110.Google Scholar
McGuffin, P. & Sargeant, M. P. (1991) Genetic markers and affective disorder. In The New Genetics of Mental Illness (eds P. McGuffin & R. Murray), pp 165–181. Oxford: Butterworth-Heinemann.Google Scholar
Medansky, R. S. & Woloshin, A. A. (1961) Darier's disease. An evaluation of its neuropsychiatric component. Archives of Dermatology, 84, 482–484.CrossRefGoogle ScholarPubMed
Milton, G. P., Peck, G. L., Fu, J. L., et al (1990) Exacerbation of Darier's disease by lithium carbonate. Journal of the American Academy of Dermatology, 23, 926–928.CrossRefGoogle ScholarPubMed
Ott, J. (1991) Analysis of Human Genetic Linkage. Baltimore: The Johns Hopkins University Press.Google Scholar
Peck, G. L., Kraemer, K. H., Wetzel, B., et al (1976) Cornifying Darier disease - a unique variant. Archives of Dermatology, 112, 495–503.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria. Rationale and reliability. Archives of General Psychiatry, 35, 773–782.CrossRefGoogle ScholarPubMed
Svendsen, I. B. & Albrectsen, B. (1959) The prevalence of dyskeratosis follicularis (Darier's disease) in Denmark. Acta Dermato-Venereologica, 39, 256–259.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.