Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-31T14:31:22.287Z Has data issue: false hasContentIssue false
  • English
  • Français

Familial Association of Albinism and Schizophrenia

Published online by Cambridge University Press:  02 January 2018

David J. Clarke  and
Mary E. Buckley
David J. Clarke*
Affiliation:
University of Birmingham Academic Unit, All Saints Hospital, Birmingham; Department of Psychiatry, University of Birmingham
Mary E. Buckley
Affiliation:
University of Birmingham Academic Unit, All Saints Hospital, Birmingham; Uffculme Clinic, Birmingham
*
∗Department of Psychiatry, Queen Elizabeth Hospital, Birmingham B15 2TH
Get access Rights & Permissions [Opens in a new window]

Abstract

Of three siblings in a family, one brother and one sister have both tyrosinase-negative oculocutaneous albinism and a psychotic disorder indistinguishable from schizophrenia. The two disorders may associate within families through genetic linkage or a failure of neurotransmitter homoeostasis.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 155 , Issue 4 , October 1989 , pp. 551 - 553
Copyright
Copyright © Royal College of Psychiatrists 1989 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Arons, B., Kosek, J. C. & Forrest, I. S. (1968) Chlorpromazine therapy in a female albino mental patient: clinical, histochemical and biochemical observations. Life Sciences, 7, 1273–1280.Google Scholar
Baron, M. (1976) Albinism and schizophreniform psychosis: a pedigree study. American Journal of Psychiatry, 133, 1070–1073.Google Scholar
Barton, D. E., Kwon, B. S. & Francke, U. (1988) Human tyrosinase gene, mapped to chromosome 11 (q14q21), defines second region of homology with mouse chromosome 7. Genomics, 3, 17–24.Google Scholar
Bassett, A. S., McGillivray, B. C., Jones, B. D., et al (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet, i, 799–801.Google Scholar
Carroll, W. M., Jay, B. S., McDonald, W. I., et al (1980) Two distinct patterns of visual evoked response asymmetry in human albinism. Nature, 286, 604–606.Google Scholar
Clarke, D. J. (1987) Paranoid schizophrenia in an Afro-Caribbean albino. Clinical Notes On-Line, 2, 2.Google Scholar
Cole, G. F., Conn, P., Jones, R. B., et al (1987) Cognitive functioning in albino children. Developmental Medicine and Child Neurology, 29, 659–665.CrossRefGoogle ScholarPubMed
Flach, F. F. & Kaplan, M. (1983) Visual perceptual dysfunction in psychiatric patients. Comprehensive Psychiatry, 24, 304–311.Google Scholar
Froggatt, P. (1960) Albinism in Northern Ireland. Annals of Human Genetics, 24, 213–238.Google Scholar
Greiner, A. C. & Nicolson, G. A. (1965) Schizophrenia-melanosis: cause or side effect? Lancet, ii, 1165–1167.Google Scholar
Guillery, R. W., Okoro, A. N. & Witkop, C. J. (1975) Abnormal visual pathways in the brain of a human albino. Brain Research, 96, 373–377.CrossRefGoogle ScholarPubMed
Jurjus, G., Moh, P. & Levy, A. B. (1989) Oculocutaneous albinism and schizophrenia-like psychosis. Journal of Nervous and Mental Disease, 177, 112.Google Scholar
Leibowitz, M. R., Dogliotti, M. & Hart, G. (1978) Schizophrenia and albinism. Dermatologica, 156, 367–370.Google Scholar
Ni Nuallain, M., O'Hare, A. & Walsh, D. (1987) Incidence of schizophrenia in Ireland. Psychological Medicine, 17, 943–948.Google Scholar
Pollack, M. H. & Manschreck, T. C. (1986) Oculocutaneous albinism and schizophrenia. Biological Psychiatry, 21, 830–833.Google Scholar
Robins, L. N., Helzer, J. E., Weissman, M. M., et al (1984) Lifetime prevalence of specific psychiatric disorders in three sites. Archives of General Psychiatry, 41, 949–958.Google Scholar
Rogawski, M. A., Funderburk, S. J. & Cederbaum, S. D. (1978) Oculocutaneous albinism and mental disorder. A report of two autistic boys. Human Heredity, 28, 81–85.Google Scholar
Scarone, S., Cazzullo, C. L. & Gambini, O. (1987) Asymmetry of lateralised hemispheric functions in schizophrenia. British Journal of Psychiatry, 151, 15–17.CrossRefGoogle ScholarPubMed
Sherrington, R., Brynjolfsson, J., Petursson, H., et at (1988) Location of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164–167.Google Scholar
Sulestrowska, H. (1967) The psychiatric aspect of generalized albinism. Polish Medical Journal, 6, 1276–1284.Google Scholar
Torrey, E. F. (1980) Schizophrenia and Civilization. London: Jason Aronson.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Witcop, C. J., Quevedo, W. C. & Fitzpatrick, T. B. (1978) Albinism. In The Metabolic Basis of Inherited Disease (eds Stanbury, J. B., Wyngaarden, J. B. & Fredrickson, D. S.). New York: McGraw-Hill.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.