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Extrapyramidal Disorders After Prolonged Phenothiazine Therapy

Published online by Cambridge University Press:  29 January 2018

P. F. Kennedy ,
H. I. Hershon  and
R. J. McGuire
P. F. Kennedy
Affiliation:
Medical Research Council Unit for Epidemiological Studies in Psychiatry, University Department of Psychiatry, Edinburgh 10
H. I. Hershon
Affiliation:
University Hospital (St. James), Leeds
R. J. McGuire
Affiliation:
University Department of Psychiatry, Leeds
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Extract

Motor disorders occurring in association with phenothiazine therapy have been widely appreciated and investigated since the advent of these drugs in the early nineteen-fifties. Published works have indicated that between 20 and 40 per cent of patients treated with phenothiazines exhibit signs of extrapyramidal dysfunction (Denham, 1961; Ayd, 1961). However, the relationship between treatment variables and the frequency of these motor disorders is not a simple one. Many factors are likely to have aetiological significance, and it seems that their occurrence is more a reflection of personal idiosyncrasy than of chemical structure, dosage or duration of treatment (Lancet, 1964).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 118 , Issue 546 , May 1971 , pp. 509 - 518
Copyright
Copyright © Royal College of Psychiatrists, 1971 

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