Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-22T08:16:27.245Z Has data issue: false hasContentIssue false

Exacerbation of Obsessive–Compulsive Symptoms Associated with Clozapine

Published online by Cambridge University Press:  02 January 2018

M. J. Eales*
Affiliation:
Tone Vale Hospital, Norton Fitzwarren, Taunton, Somerset TA4 1DB (formerly Senior Registrar in Psychiatry, Eastbourne Health Authority)
A. O. Layeni
Affiliation:
Eastbourne Health Authority
*
Correspondence

Abstract

We report a case in which clozapine caused a marked and disabling exacerbation of obsessive–compulsive rituals in a patient with schizophrenia.

Type
Short Papers
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Baldessarini, R. & Frankenburg, P. (1991) Clozapine: a novel antipsychotic agent. New England Journal of Medicine, 323, 746754.Google Scholar
Benkelfat, C., Murphy, D. L., Zohar, J., et al (1989) Clomipramine in obsessive-compulsive disorder: further evidence for a serotonergic mechanism of action. Archives of General Psychiatry, 46, 2328.Google Scholar
Brewerton, T. D. & Shannon, M. (1992) Possible clozapine exacerbation of bulimia. American Journal of Psychiatry, 149, 1408.Google Scholar
Cassady, S. L. & Thaker, G. K. (1992) Addition of fluoxetine to clozapine. American Journal of Psychiatry, 149, 1274.Google ScholarPubMed
Coward, D. M. (1992) General pharmacology of clozapine. British Journal of Psychiatry, 160 (suppl. 17), 511.Google Scholar
Gaertner, H. J., Fischer, E. & Hoss, J. (1989) Side effects of clozapine. Psychopharmacology, 99 (suppl.), S97S100.CrossRefGoogle ScholarPubMed
Goodman, W. K., Price, L. H., Rasmussen, S. A., et al (1989) The Yale–Brown Obsessive Compulsive Scale. Archives of General Psychiatry, 46, 10061011.Google Scholar
Murphy, D. L., Zohar, J., Benkelfat, C., et al (1989) Obsessive-compulsive disorder as a 5-HT subsystem-related behavioural disorder. British Journal of Psychiatry, 155 (suppl. 8), 1524.CrossRefGoogle Scholar
Naber, D., Holzbach, D., Perro, C., et al (1992) Clinical management of clozapine patients in relation to efficacy and side effects. British Journal of Psychiatry, 160 (suppl. 17), 5459.Google Scholar
Safferman, A., Lieberman, J. A., Kane, J. M., et al (1991) Update on the clinical efficacy and side effects of clozapine. Schizophrenia Bulletin, 17, 247261.Google Scholar
Wander, T. J., Nelson, A., Okazaki, H., et al (1987) Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro. European Journal of Pharmacology, 143, 279282.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.