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Evidence for a Pseudoautosomal Locus for Schizophrenia

II: Replication of a Non-random Segregation of Alleles at the DXYS14 Locus

Published online by Cambridge University Press:  02 January 2018

T. D'Amato ,
D. Campion ,
Ph. Gorwood ,
M. Jay ,
O. Sabate ,
C. Petit ,
M. Abbar ,
A. Malafosse ,
M. Leboyer  and
D. Hillaire
...Show all authors
T. D'Amato
Affiliation:
CNRS, F-91198 Gif-sur-Yvette, and CHS “Le Vinatier” (Pr Dalery), F-69677 Lyon-Bron, France
D. Campion
Affiliation:
Département de Recherche, F-76300 Sotteville-les-Rouens, and Laboratoire de Génétique Epidémiologique, INSERM U-155, Château de Longchamp, F-75016 Paris
Ph. Gorwood
Affiliation:
INSERM U-155, Cháteau de Longchamp, F-75016 Paris
M. Jay
Affiliation:
97460 St Paul, La Réunion
O. Sabate
Affiliation:
CNRS, F-91198 Gif-sur-Yvette
C. Petit
Affiliation:
INSERM-U-163, CNRS UA-271, Institut Pasteur, F-75015 Paris
M. Abbar
Affiliation:
F-34059 Montpellier
A. Malafosse
Affiliation:
CNRS, F-91198 Gif-sur-Yvette
M. Leboyer
Affiliation:
F-75651 Paris
D. Hillaire
Affiliation:
INSERM, 97405 St Denis, La Réunion
F. Clerget-Darpoux
Affiliation:
INSERM U-155, Château de Longchamp, F-75016 Paris
J. Feingold
Affiliation:
INSERM U-155, Château de Longchamp, F-75016 Paris
G. Waksman
Affiliation:
CNRS, F-91198 Gif-sur-Yvette
J. Mallet*
Affiliation:
CNRS, F-91198 Gif-sur-Yvette, France
*
∗Laboratoire NBCM, CNRS UPR0023, 1 Avenue de la Terrasse, 91–198 Gif-sur-Yvette, France
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Abstract

Because of an association between sexual aneuploidies and schizophrenia, and because schizophrenic siblings have been found to be more often of the same than of the opposite sex, the susceptibility locus for schizophrenia is thought to lie within the pseudoautosomal region of the sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 trios, and 2 quartets of affected siblings, and found support for non-random segregation of alleles at the DXYS14 locus in affected siblings. These findings are consistent with the pseudoautosomal hypothesis for schizophrenia and favour a genetic linkage between DXYS 14 and the disease.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 1 , July 1992 , pp. 59 - 62
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1960) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC, APA.Google Scholar
Baron, M., Hasnis, L. & Gruen, R. (1981) The Schedule for Schizotypal Personality: a diagnostic interview for schizotypal features. Psychiatry Research, 4, 213–228.Google Scholar
Burgoyne, P. S. (1986) Sex chromosomes, mammalian X and Y crossover. Nature, 319, 258–259.CrossRefGoogle ScholarPubMed
Clerget-Darpoux, F., Bonaiti-Pellie, C., & Hochez, J. (1987) Power and robustness of the linkage homogeneity test in genetic analysis of common disorders. Journal of Psychiatry Research, 21, 625–630.CrossRefGoogle ScholarPubMed
Collinge, J., DeLisi, L. E., Boccio, A., et al (1991) Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs. British Journal of Psychiatry, 158, 624–629.Google Scholar
Cooke, H. J., Brown, W. R. A. & Rappold, G. A. (1985) Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal. Nature, 317, 687–692.Google Scholar
Crow, T. J. (1988) Sex chromosomes and psychosis. The case for a pseudoautosomal locus. British Journal of Psychiatry, 153, 675–683.CrossRefGoogle ScholarPubMed
Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Concordance by sex in sibling pairs with schizophrenia is paternally inherited. Evidence for a pseudoautosomal locus. British Journal of Psychiatry, 155, 92–97.Google Scholar
Crow, T. J., DeLisi, L. E., Johnstone, E. C. (1990) In reply … A locus closer to the telomere? British Journal of Psychiatry, 156, 416–420.CrossRefGoogle Scholar
Curtis, D. & Gurling, H. (1990) Unsound methodology in investigating a pseudoautosomal locus in schizophrenia. British Journal of Psychiatry, 156, 415–416.Google Scholar
DeLisi, L. E. Goldin, L. R., Maxwell, M. E., et al (1987) Clinical features of illness in siblings with schizophrenia or schizoaffective disorders. Archives of General Psychiatry, 44, 891–896.CrossRefGoogle ScholarPubMed
DeLisi, L. E. & Crow, T. J. (1989) Evidence for a sex chromosome locus for schizophrenia. Schizophrenia Bulletin, 15, 431–440.CrossRefGoogle ScholarPubMed
Fyer, A., Endicott, J., Manuzza, S., et al (1985) Schedule for Affective Disorders and Schizophrenia, life time anxiety version. In Anxiety Disorders Clinic. New York: New York State Psychiatric Institute Google Scholar
Goodfellow, P., Banting, G., Sheer, D., et al (1983) Genetic evidence that a Y-linked gene is homologous to a gene on the X chromosome. Nature, 302, 346–349.Google Scholar
Goodfellow, P., Darling, S. M., Thomas, N. S., et al (1986) A pseudoautosomal gene in man. Science, 234, 740–742.Google Scholar
Gorwood, P. H., Leboyer, M., Hillaire, D., et al (1991) Cytogenetic studies of familial schizophrenics. Biological Psychiatry, 29, 624–625.Google Scholar
Gouoh, N. M., Gearing, D. P., Nicola, N. A., et al (1990) Localization of the human GM–CSF receptor gene to the X-Y pseudoautosomal region. Nature, 345, 734–736.CrossRefGoogle Scholar
Green, J. R. & Woodrow, J. C. (1977) Sibling method for detecting HLA-linked genes in disease. Tissue Antigens, 9, 31–35.CrossRefGoogle ScholarPubMed
Kallman, F. J. (1946) The genetic theory of schizophrenia. American Journal of Psychiatry, 103, 309–322.CrossRefGoogle Scholar
Leboyer, M., Jay, M., d'Amato, T., et al (1990) Subtyping familial schizophrenia: reliability, concordance, and stability. Psychiatry Research, 34, 77–88.Google Scholar
Lewine, R. J. (1988) Gender and schizophrenia. In Handbook of Schizophrenia, Vol. 3, Nosology, Epidemiology, and Genetics (eds Tsuang, M. T. & Simson, J C.). Amsterdam: Elsevier.Google Scholar
McGue, M., Gottesman, I. I. & Rao, D. C. (1985) Resolving genetic models for the transmission of schizophrenia. Genetic Epidemiology, 1, 99–110.CrossRefGoogle Scholar
McGue, M. & Gottesman, I. I. (1989) Genetic linkage in schizophrenia: perspective from genetic epidemiology. Schizophrenia Bulletin, 15, 453–463.Google Scholar
Petit, C., Levilliers, J. & Weissenbach, J. (1988) Physical mapping of the human pseudo-autosomal region; comparison with genetic linkage map. EMBO Journal, 7, 2369–2376.Google Scholar
Rosanoff, A. J., Handy, L. M., Plesset, I. R., et al (1934) Etiology of so-called schizophrenic psychosis. With special references to their occurrence in twins. American Journal of Psychiatry, 91, 247–286.CrossRefGoogle Scholar
Rosenthal, D. (1962) Familial concordance by sex with respect to schizophrenia. Psychological Bulletin, 59, 401–421.Google Scholar
Rouyer, F., Simmler, M. C., Johnsson, C., et al (1986) A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes. Nature, 319, 291–295.Google Scholar
Sherrington, R., Brynjolfsson, J., Petursson, H., et al (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164–167.Google Scholar
Simmler, M. C., Rouyer, F., Vergnaud, G., et al (1985) Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes. Nature, 317, 692–697.CrossRefGoogle ScholarPubMed
Simmler, M. C., Johnsson, C., Pettit, C., et al (1987) Two highly polymorphic minisatellites from the pseudoautosomal region of the human sex chromosomes. EMBO Journal, 6, 963–969.CrossRefGoogle ScholarPubMed
Sturt, E. & Shur, E. (1985) Sex concordance for schizophrenia in proband-relative pairs. British Journal of Psychiatry, 147, 44–47.Google Scholar
Suarez, B. K. & van Eerdewegh, P. (1984) A comparison of three affected sibpair scoring methods to detect HLA-linked disease susceptiblity genes. American Journal of Medical Genetics, 18, 135–146.Google Scholar
Tsuang, M. T. (1967) A study of pairs of sibs both hospitalised for mental disorder. British Journal of Psychiatry, 113, 283–300.CrossRefGoogle ScholarPubMed
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