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Evidence for a Pseudoautosomal Locus for Schizophrenia

I: A Replication Study Using Phenotype Analysis

Published online by Cambridge University Press:  02 January 2018

Ph. Gorwood ,
M. Leboyer ,
T. D'Amato ,
M. Jay ,
D. Campion ,
D. Hillaire ,
J. Mallet  and
J. Feingold
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Abstract

A locus for schizophrenia within the pseudoautosomal region of chromosomes X and Y has been suggested by Crow on the basis of epidemiological data. The present report replicates this finding in a sample of 38 French multiply affected families with schizophrenia. Sibship and pairwise analysis, with or without weighted-pair correction, with three different systems of family classifications, showed there to be an excess of same-sex pairs in paternally derived sibships, as predicted by the pseudoautosomal hypothesis.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 1 , July 1992 , pp. 55 - 58
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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