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Evidence Against a Genetic Relationship between Tourette's Syndrome and Anxiety, Depression, Panic and Phobic Disorders

Published online by Cambridge University Press:  02 January 2018

David L. Pauls ,
James F. Leckman  and
Donald J. Cohen
David L. Pauls*
Affiliation:
Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06510, USA
James F. Leckman
Affiliation:
Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06510, USA
Donald J. Cohen
Affiliation:
Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06510, USA
*
∗Correspondence
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Abstract

Analyses were undertaken to examine whether a wide range of psychiatric disorders, including anxiety, affective, substance abuse and psychotic disorders, represent variant manifestations of Tourette's syndrome (TS). Previous studies have suggested that chronic tics (CT) and obsessive-compulsive disorder (OCD) are variant expressions of TS since both CT and OCD are elevated among relatives of TS probands. In the current study, no other psychiatric disorder was significantly elevated among the relatives who did not have TS, CT or OCD when compared with a control sample. These findings are not consistent with the hypothesis that a wide range of psychiatric and behavioural disorders are variant expressions of TS.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 2 , February 1994 , pp. 215 - 221
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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