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The Estimated Density of D2 Striatal Receptors in Schizophrenia

A Study with Positron Emission Tomography and 76Br-Bromolisuride

Published online by Cambridge University Press:  02 January 2018

J. L. Martinot ,
M. L. Paillère-Martinot ,
C. Loc'h ,
P. Hardy ,
M. F. Poirier ,
B. Mazoyer ,
B. Beaufils ,
B. Mazière ,
J. F. Allilaire  and
A. Syrota
J. L. Martinot*
Affiliation:
Service hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, département biologie, 91406, Orsay, France
M. L. Paillère-Martinot
Affiliation:
Service de psychopathologie de l'enfant et de l'adolescent, hopital de la Salpêtrière
C. Loc'h
Affiliation:
Service hospitalier Frédéric Joliot
P. Hardy
Affiliation:
Service de psychiatric hopital de Bicêtre
M. F. Poirier
Affiliation:
Service hospitalo-universitaire, hopital Ste Anne
B. Mazoyer
Affiliation:
Service hospitalier Frédéric Joliot
B. Beaufils
Affiliation:
Service de psychiatrie, hopital Bicêtre
B. Mazière
Affiliation:
Service hospitalier Frédéric Joliot
J. F. Allilaire
Affiliation:
Service de psychiatrie, hopital de la Salpêtrière
A. Syrota
Affiliation:
Service hospitalier Frédéric Joliot
*
∗Correspondence
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Abstract

The striatal D2 receptors of 19 untreated schizophrenics and 14 normal control subjects were investigated with PET and 76Br-bromolisuride. The ratio of radioactivity in the striatum to that in the cerebellum was taken as an index of the striatal D2 receptor density. There was no significant difference between the control and the schizophrenic groups, nor any difference between subgroups of patients defined by clinical type or course of illness, and no relationship between the striatum:cerebellum activity ratio and SANS or SAPS ratings of symptoms. Unlike in the controls, this ratio was not correlated with age in schizophrenics. This study suggests that there is no quantitative abnormality of striatal D2 dopamine receptors in schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 158 , Issue 3 , March 1991 , pp. 346 - 350
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Andreasen, N. C. (1982) Negative vs positive schizophrenia: definition and validation. Archives of General Psychiatry, 39, 789–794.CrossRefGoogle Scholar
Andreasen, N. C. Carson, R. Diksik, M. et al (1988) Workshop on schizophrenia, PET, and dopamine D 2 receptors in the human neostriatum. Schizophrenia Bulletin, 14, 474–484.Google Scholar
Baron, J. C. & Maziere, B. (1986) Positron emission tomography of central receptors in humans. In PET and NMR: Neurochemistry In Vivo (ed. Battistini, L.). New York: Alan R. Liss.Google Scholar
Baron, J. C. Maziere, B. & Loch, C. et al (1986) Loss of striatal 76Br-bromospiperone binding sites demonstrated by positron emission tomography in progressive supranuclear palsy. Journal of Cerebral Blood Flow and Metabolism, 6, 131–136.Google Scholar
Bowers, M. B. (1974) Central dopamine turnover in schizophrenic syndromes. Archives of General Psychiatry, 31, 50–54.Google Scholar
Creese, I. Burt, D. R. & Snyder, S. H. (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science, 192, 481–483.CrossRefGoogle ScholarPubMed
Crow, T. J. (1987) The dopamine hypothesis survives, but there must be a way ahead. British Journal of Psychiatry, 151, 460–465.CrossRefGoogle ScholarPubMed
Crow, T. J. Cross, A. J. Johnson, J. A. et al (1984) Catecholamines and schizophrenia: an assessment of the evidence. In Catecholamines. Neuropharmacology and Central Nervous System: Therapeutic Aspects (eds Usdin, E. Carlsson, A. Dahlstrom, A. et al). New York: Alan R. Liss.Google Scholar
Farde, L. Wiesel, F. A. Hall, H. et al (1987) No D2 receptor increase in PET study of schizophrenia. Archives of General Psychiatry, 44, 671–672.Google Scholar
Farde, L. Wiesel, F. A. Stone-Elander, S. et al (1990) D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride. Archives of General Psychiatry, 47, 213–219.Google Scholar
Herold, S. Leenders, K. L. Turton, D. R. et al (1985) Dopamine receptor binding in schizophrenic patients as measured with 11C-methylspiperone and PET. Journal of Cerebral Blood Flow and Metabolism, 5, 5191–5195.Google Scholar
Keller, H. H. Schaffner, R. & Haefely, W. (1976) Interaction of benzodiazepines with neuroleptics at central dopamine neurons. Naunyn Schmiedeberg's Archives of Pharmacology, 294, 1–7.Google Scholar
Kornhuber, J. Riederer, P. Reynolds, G. P. et al (1989) 3H-spiperone binding sites in post-mortem brains from schizophrenic patients: relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms. Journal of Neural Transmission, 75, 1–10.CrossRefGoogle ScholarPubMed
Mackay, A. V. P. Iversen, L. L. Rossor, M. et al (1982) Increased brain dopamine and dopamine receptors in schizophrenia. Archives of General Psychiatry, 39, 991–997.Google Scholar
Martinot, J. L. Peron-Magnan, P. Huret, J. D. et al (1990) Striatal D2 dopaminergic receptors assessed by positron emission tomography and 76Br-bromospiperone in untreated schizophrenics. American Journal of Psychiatry, 147, 44–50.Google Scholar
Mazière, B. Loch, C. Stulzaft, O. et al (1986) [76Br] bromolisuride: a new tool for quantitative in vivo imaging of D2–dopamine receptors. European Journal of Pharmacology, 127, 239–247.CrossRefGoogle Scholar
Mazière, B. Loch, C. Stulzaft, O. et al (1990) PET imaging of D2 receptors in the living baboon or human brain in normal and pathological conditions using 76Br-bromolisuride. In Neuropsychopharmacology (eds Bunney, W. E. Hippius, H. Laakman, G. et al), pp 409–417. Heidelberg: Springer-Verlag (in press).Google Scholar
Post, R. M. Fink, E. Carpenter, W. T. et al (1975) Cerebrospinal fluid anime metabolites in acute schizophrenia. Archives of General Psychiatry, 32, 1063–1069.CrossRefGoogle Scholar
Sedvall, G. Farde, L. Persson, A. et al (1986) Imaging of the neurotransmitter receptors in the living human brain. Archives of General Psychiatry, 43, 995–1005.CrossRefGoogle ScholarPubMed
Seeman, P. (1987) Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse, 1, 133–152.Google Scholar
Seeman, P. Bzowej, N. H. Guan, A. C. et al (1987) Human brain dopamine receptors in children and aging adults. Synapse, 1, 399–404.Google Scholar
Wong, D. F. Wagner, H. N. Pearlson, G. et al (1985) Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report. Psychopharmacology Bulletin, 21, 595–597.Google Scholar
Wong, D. F. Wagner, H. N. Tune, L. E. et al (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234, 1558–1563.Google Scholar
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