Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-31T14:51:05.640Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficacy of Tianeptine in Comparative Trials versus Reference Antidepressants An Overview

Published online by Cambridge University Press:  06 August 2018

J. D. Guelfi
J. D. Guelfi*
Affiliation:
Clinique des Maladies Mentales et de l'Encephale, Hôpital Sainte Anne, Paris, France
Get access Rights & Permissions [Opens in a new window]

Extract

The clinical properties of tianeptine have been assessed in double-blind controlled studies, which involved depressed patients fulfilling DSM-III criteria for either major depression — single episode or recurrent (without melancholia and psychotic features) — or dysthymic disorder —with or without an additional diagnosis of alcohol abuse or dependence. Five studies have compared tianeptine with reference antidepressants: its efficacy has been found to be similar to that of amitriptyline in depressed out-patients. However, these data need to be confirmed by other controlled trials v. reference drugs and by at least two placebo-controlled studies. Tianeptine does not induce sleep disorders, anticholinergic effects, or modifications of cardiovascular variables or biological parameters (renal, haematological, or hepatic). After the end of treatment, the only signs of withdrawal have been some disturbances of sleep.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 160 , Issue S15: Stress, Serotonin and Tianeptine , February 1992 , pp. 72 - 75
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Baccino, E., Bressollette, L., Mother, D., et al (1989) Tianeptine an antidepressant with an original action on platelet 5HT uptake in elderly patients. Book of Abstracts. International Symposium on Serotonin From Cell Biology to Pharmacology and Therapeutics, Florence, March 29–April 1, 171.Google Scholar
Bersani, G., Pasini, A., Brancato, T., et al (1989) Serotonina e depressione: studio multicentrico controllata tianeptina versus amitriptylina. XXXVII Congresso Nazionale della Societa Italiana di Psichiatria Roma – 6−11 febbraio 1989, CIC Edizioni Internazionali, 1243–1249.Google Scholar
Delalleau, B., Dulcire, C., Le Moine, P., et al (1988) Analysis of the side-effects of tianeptine. Clinical Neuropharmacology, 11 (suppl. 2), S83–S89.Google ScholarPubMed
Derogatis, L. R., Lipman, R. S., Rickels, K., et al (1974) The Hopkins Symptom Check List (HSCL): a self-report symptom inventory. Behavioral Science, 19, 1–15.Google Scholar
Dilsaver, S. C. (1989) Antidepressant withdrawal syndromes. Phenomenology and pathophysiology. Acta Psychiatrica Scandinavica, 79, 113–117.Google Scholar
Dresse, A. & Scuvée-Moreau, J. (1988) Electro-physiological effects of tianeptine on rat locus coeruleus, raphe dorsalis and hippocampus activity. Clinical Neuropharmacology, 11 (suppl. 2), 551–558.Google Scholar
Food & Drug Administration (1977) Guidelines for the clinical evaluation of antianxiety drugs.Google Scholar
Guelfi, J. D., Dreyfus, J. F. & Pull, C. B. (1983) A check-list for the assessment of somatic symptoms (CHESS). Principal component and cluster analysis. VIIth World Congress of Psychiatry, Vienna, Abstracts, Ciba-Geigy, p. 454.Google Scholar
Guelfi, J. D., Pichot, P. & Dreyfus, J. F. (1989) Efficacy of tianeptine in anxious depressed patients. Results of a controlled multicentre trial versus amitriptyline. Neuropsychobiology, 22, 41–48.CrossRefGoogle ScholarPubMed
Hamilton, M. (1959) The assessment of anxiety states by rating. British Journal of Psychology, 32, 50–55.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56.Google Scholar
Hamilton, M. (1969) Standardized assessment and recording of depressive symptoms. Psychiatry, Neurology & Neurosurgery, 72, 201–205.Google ScholarPubMed
Lôo, H., Malka, R., Defrance, R., et al (1988) Tianeptine and amitriptyline: controlled double-blind trial in depressed alcoholic patients. Neuropsychobiology, 19, 79–85.CrossRefGoogle ScholarPubMed
Malka, R. (1988) Role of drug therapies in the treatment of alcoholism: alcohol and anxiety-alcohol and depression. Clinical Neuropharmacology, 11 (suppl. 2), S69–S73.Google ScholarPubMed
Merikangas, K. R., Leckman, J. F., Prusoff, B. A., et al (1985) Familial transmission of depression and alcoholism. Archives of General Psychiatry, 42, 367–372.CrossRefGoogle ScholarPubMed
Mennini, T. & Garattini, S. (1987) Effects of long term treatment with antidepressants on 3-H serotonin uptake and 3-H imipramine binding in rat brain. Journal of Receptor Research, 7, 1–4.Google Scholar
Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.CrossRefGoogle ScholarPubMed
Ostaptzeff, G. (1981) Etude contrôlée à double insu versus imipramine de l'efficacité de la tianeptine dans des états dépressifs non psychotiques. In: Biological Psychiatry. Proceedings of the IIIrd World Congress of Biological Psychiatry, Stockholm, Sweden; Elsevier/North Holland, 597–600.Google Scholar
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799–812.Google Scholar
Poignant, J. C. (1981) Etude pharmacologique d'un nouvel antidépresseur: la tianeptine. In: Biological Psychiatry. Proceedings of the IIIrd World Congress of Biological Psychiatry, Stockholm, Sweden; Elsevier/North Holland, 573–578.Google Scholar
Renaud, B., Mocaër, E., Weitsch, A. F., et al (1987) Stimulation of serotonin uptake induced by a new antidepressant. Proceedings of the ECNP Constituent meeting, Brussels. Pharmacopsychiatry, 21, 66.Google Scholar
Warrington, S. J., Padgham, C. & Lader, M. (1989) The cardiovascular effects of antidepressants. Psychological Medicine (Monograph Supplement), 16, 1–32.Google Scholar
Weiss, C., Gorceix, A., Kindynis, S., et al (1981) Etude contrôlée à double insu versus nomifensine de l'activité et du délai d'action d'un nouvel antidépresseur, la tianeptine. In: Biological Psychiatry. Proceedings of the IIIrd World Congress of Biological Psychiatry, Stockholm, Sweden; Elsevier/North Holland, 593–596.Google Scholar
Weissman, M. M. & Myers, J. K. (1980) Clinical depression in alcoholism. American Journal of Psychiatry, 137, 372–373.Google Scholar
Winokur, G. (1979) Alcoholism and depression in the same family. In: Alcoholism & Affective Disorders: Clinical Genetic and Biochemical Studies (eds Goodwin, D. J. & K Erikson, C.), pp. 9–19. New York: SP Medical Scientific Books.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.