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Efficacy of Lithium Prophylaxis in Clinical Practice

Published online by Cambridge University Press:  02 January 2018

H. R. Markar*
Affiliation:
Fulbourn Hospital, Fulbourn, formerly Registrar, Royal Edinburgh Hospital, Edinburgh
A. J. Mander
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh
*
Fulbourn Hospital, Fulbourn, Cambridge CB1 5EF

Abstract

The efficacy of lithium prophylaxis in bipolar affective disorder in clinical practice was investigated. Comparison was made between 41 patients who were prescribed prophylactic lithium after two admissions in two years or three admissions in five years and a group of patients who did not receive lithium. The benefits conferred by the prescription of this drug were modest compared with the results from clinical trials.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists 1989 

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References

Angst, J., Dittrich, A. & Grof, P. (1969) Course of endogenous affective psychoses and its modification by prophylactic administration of imipramine and lithium. International Pharmacopsychiatry, 2, 111.Google Scholar
American Psychiatric Association (1980) Diagnostic & Statistical Manual of Mental Disorders (DSM–III). Washington DC: APA.Google Scholar
Baastrup, P. C., Poulson, J. C., Schou, M., et al (1970) Prophylactic lithium: double blind discontinuation in manic depressive disorders. Lancet, ii, 326360.Google Scholar
Baldessarini, R. J. (1970) Frequency of diagnosis of schizophrenia versus affective disorders from 1944 to 1968. American Journal of Psychiatry, 127, 759763.Google Scholar
Bouman, T. K., Niemantsverdriet-Van Kampan, J. G., Ormel, J. et al (1986) The effectiveness of lithium prophylaxis in bipolar and unipolar depressions and schizoaffective disorders. Journal of Affective Disorders, 11, 275280.Google Scholar
Cade, J. F. J. (1949) Lithium salts in the treatment of psychotic excitement. Medical Journal of Australia, 1, 349352.CrossRefGoogle Scholar
Coppen, A., Noguera, R., Bailey, J., et al (1971) Prophylactic lithium in affective disorders – a controlled trial. Lancet, ii, 275279.Google Scholar
Dickson, W. E. & Kendell, R. E. (1986) Does maintenance lithium therapy prevent recurrences of mania under ordinary clinical conditions. Psychological Medicine, 16, 521530.Google Scholar
Fleiss, J. L., Dunner, D. L., Stallone, F. & Fieve, R. R. (1976) The Life Table – a method for analysing longitudinal studies. Archives of General Psychiatry, 33, 107112.Google Scholar
Grof, P. (1987) Admission rates and lithium therapy. British Journal of Psychiatry, 150, 264265.Google Scholar
Grof, P., Schou, M., Angst, M., et al (1970) Methodological problems of prophylactic lithium in recurrent affective disorders. British Journal of Psychiatry, 116, 599619.Google Scholar
Hullin, R. P., McDonald, R. & Allsopp, M. N. E. (1972) Prophylactic lithium in recurrent disorders. Lancet, i, 10441046.Google Scholar
Mander, A. J. (1986) Is lithium justified after one manic episode? Acta Psychiatrica Scandinavica, 73, 6067.Google Scholar
Mander, A. J. & Loudon, J. B. (1988) Rapid recurrence of mania following abrupt discontinuation of lithium. Lancet, ii, 1517.CrossRefGoogle Scholar
Masterton, G., Warner, M. & Roxburgh, B. (1988) Supervising lithium – a comparison of a lithium clinic, psychiatric out-patient clinic and general practice. British Journal of Psychiatry, 152, 535538.Google Scholar
Parker, H., O'Donnell, M. & Walter, S. (1985) Changes in the diagnosis of the functional psychoses associated with the introduction of lithium. British Journal of Psychiatry, 146, 377382.Google Scholar
Prien, R. F., Caffey, E. M. & Klett, C. J. (1973) Prophylactic efficacy of lithium carbonate in manic-depressive illness. Archives of General Psychiatry, 28, 337341.Google Scholar
Prien, R. F., Kupfer, D. J., Mansky, P. A., et al (1984) Drug therapy and the prevention of recurrences in unipolar and bipolar disorders. Archives of General Psychiatry, 41, 10961104.Google Scholar
Symonds, R. L. & Williams, P. (1981) Lithium and the changing incidence of mania. Psychological Medicine, 11, 193196.Google Scholar
Siegel, S. (1956) Non-Parametric Statistics in Behavioural Science. Tokyo: McGraw Hill.Google Scholar
Tyrer, S. P. (1985) Lithium in the treatment of mania. Journal of Affective Disorders, 8, 251257.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Diseases (ICD–9). Geneva: WHO.Google Scholar
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