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The Effects of Weight Change on the Dexamethasone Suppression Test in Depressed and Anorexic Patients

Published online by Cambridge University Press:  29 January 2018

I. Schweitzer ,
K. P. Maguire ,
J. W. G. Tiller ,
A. H. Gee ,
L. C. Harrison  and
B. M. Davies
I. Schweitzer*
Affiliation:
Department of Psychiatry
K. P. Maguire
Affiliation:
Department of Psychiatry
J. W. G. Tiller
Affiliation:
Department of Psychiatry
A. H. Gee
Affiliation:
Endocrine Laboratory, Department of Diabetes and Endocrinology
L. C. Harrison
Affiliation:
Department of Psychiatry
B. M. Davies
Affiliation:
Department of Psychiatry, University of Melbourne
*
University of Melbourne, Clinical Sciences Block, Royal Melbourne Hospital, Victoria 3050, Australia
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Abstract

Prior studies on weight change and hypothalmic-pituitary-adrenal (HPA) axis functioning are reviewed. Data on 58 depressed and eight anorexic patients is presented. No significant difference in the frequency of cortisol non-suppression in the dexamethasone suppression test (DST) was found between depressed patients with a history of weight loss and those without, nor between depressed patients who lost weight during their first week in hospital and those who did not. Mean weight loss of suppressors did not significantly differ from that of non-suppressors. Of 12 patients whose DST normalised during their stay in hospital, only four gained weight. Five anorexics who were non-suppressors were <70% of their ideal body weight (IBW), while three suppressor anorexics were ≧70% IBW. These results indicate that mild to moderate weight change is not a significant influence on DST response in depression.

Type
Papers
Information
The British Journal of Psychiatry , Volume 149 , Issue 6 , December 1986 , pp. 751 - 755
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Berger, M., Pirke, K.-M., Doerr, P., Krieg, J. C. & Von-Zerssen, D.(1983) Influence of weight loss on the dexamethasone suppression test. Archives General Psychiatry, 40, 585–586.CrossRefGoogle ScholarPubMed
Berger, M., Pirke, K.-M., Doerr, P., Krieg, J. C. & Von-Zerssen, D.(1984) The limited utility of the dexamethasone suppression test for the diagnostic process in psychiatry. British Journal of Psychiatry, 145, 372–382.CrossRefGoogle ScholarPubMed
Carroll, B. J.(1971) Metabolic studies in depressive illness. PhD. Thesis. University of Melbourne.Google Scholar
Carroll, B. J.(1985) Dexamethasone suppression test: A review of contemporary confusion. Journal of Clinical Psychiatry, 46, 18–24.Google Scholar
Carroll, B. J., Curtis, G. C., Mendels, J., Tarika, J., Albala, A. A., Hasket, R. F., James, N. M., Kronfol, Z. Lohr, N., Steiner, M., De Vigne, J. P. & Young, E.(1976) Neuroendocrine regulation in depression I Limbic system-adrenocortical dysfunction. Archives of General Psychiatry, 33, 1039–1044.CrossRefGoogle ScholarPubMed
Carroll, B. J., Curtis, G. C., Mendels, J., Tarika, J., Albala, A. A., Hasket, R. F., James, N. M., Kronfol, Z. Lohr, N., Steiner, M., De Vigne, J. P. & Young, E., Feinberg, M. & Greden, J. F.(1981) A specific laboratory test for the diagnosis of melancholia. Archives of General Psychiatry, 38, 15–22.CrossRefGoogle ScholarPubMed
Coppen, A., Harwood, J., Wood, K.(1984) Depression, weight loss and the dexamethasone suppression test. British Journal of Psychiatry, 145, 88–90.CrossRefGoogle ScholarPubMed
Edelstein, C. K., Roy-Byrne, P., Fawzy, F. I. & Dörnfeld, L.(1983) Effects of weight loss on the dexamethasone suppression test. American Journal Psychiatry, 140, 338–341.Google ScholarPubMed
Feinberg, M. & Carroll, B. J.(1984) Biological markers and endogenous depression. Archives of General Psychiatry, 41, 1080–1085.CrossRefGoogle ScholarPubMed
Fighter, M. M., Doerr, P., Pirke, K.M. & Lund, R.(1982) Behaviour, attitude, nutrition and endocrinology in anorexia nervosa. Acta Psychiatrica Scandinavica, 66, 429–444.CrossRefGoogle Scholar
Galvao Teles, A., Graves, L. & Burke, C. W.(1976) Free cortisol in obesity. Acta Endocrinologica, 81, 321–329.Google ScholarPubMed
Gwirtsman, H. E. & Gerner, R. H.(1981) Neurochemical abnormalities in anorexia nervosa; similarities to affective disorders. Biological Psychiatry, 16, 991–995.Google ScholarPubMed
Hirschfeld, R. M., Koslow, S. H. & Kupfer, D. S.(1983) The clinical utility of the DST in psychiatry. Summary of a NIMH Workshop. Journal American Medical Association, 250, 2172–2174.CrossRefGoogle Scholar
Holsboer, F., Philipp, M. & Gerken, A.(1984) Dexamethasone suppression test and weight loss (Letter). Psychiatry Research, 13, 353–354.CrossRefGoogle Scholar
Kline, M. D. & Beeber, A. R.(1983) Weight loss and the dexamethasone suppression test. (Letter). Archives of General Psychiatry, 40, 1034.CrossRefGoogle Scholar
Sachar, E. H., Hellman, J. H., Fukushima, D. K. & Gallagher, T. F.(1970). Cortisol Production in Depressive Illness. Archives of General Psychiatry, 23, 289–298.CrossRefGoogle ScholarPubMed
Smith, S. R., Bledsoe, T. & Chhetri, M. K.(1975) Cortisol metabolism and the pituitary-adrenal axis in adults with protein calorie malnutrition. Journal of Clinical Endocrinology and Metabolism, 40, 43–52.CrossRefGoogle ScholarPubMed
Targum, S. D.(1983) Reported weight loss and the dexamethasone suppression test. (Letter). Psychiatry Research, 9, 173–174.CrossRefGoogle Scholar
Walsh, B. T.(1982) Endocrine disturbances in anorexia nervosa and depression. Psychosomatic Medicine, 44, 85–91.CrossRefGoogle ScholarPubMed
Weiner, H.(1977) Psychobiology and Human Disease, New York: Elsevier.Google Scholar
Yerevanian, B. L., Baciewicz, G. J., Iker, H. P. & Privitera, M. R.(1984) The influence of weight loss on the dexamethasone suppression test. Psychiatry Research, 12, 155–160.CrossRefGoogle ScholarPubMed
Zimmerman, M., Pfohl, B. M. & Coryell, W. H.(1984) Appetite and weight change and the dexamethasone suppression test. Biological Psychiatry, 19, 923–928.Google ScholarPubMed
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