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The Effect of Long Term Phenothiazine Therapy on Plasma Prolactin

Published online by Cambridge University Press:  29 January 2018

R. G. Wilson ,
J. R. Hamilton ,
W. D. Boyd ,
A. P. M. Forrest ,
E. N. Cole ,
A. R. Boyns  and
K. Griffiths
R. G. Wilson
Affiliation:
Department of Surgery, General Hospital, Nottingham
J. R. Hamilton
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh
W. D. Boyd
Affiliation:
Royal Edinburgh Hospital, Morningside Park, Edinburgh
A. P. M. Forrest
Affiliation:
University Department of Clinical Surgery, Royal Infirmary, Edinburgh
E. N. Cole
Affiliation:
Tenovus Institute for Cancer Research, Cardiff
A. R. Boyns
Affiliation:
Tenovus Institute for Cancer Research, Cardiff
K. Griffiths
Affiliation:
Tenovus Institute for Cancer Research, Cardiff
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Summary

Plasma prolactin has been estimated in 69 psychiatric in-patients receiving either thioridazine (20–300 mg./day) or chlorpromazine (50–200 mg./day) or other phenothiazines. A homologous radioimmuno-assay was used which depends on an antiserum to human amniotic prolactin. Prolactin levels were significantly increased in these patients compared with control patients, and were dose related. Simultaneous estimation of growth hormone revealed normal levels.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 127 , Issue 1 , July 1975 , pp. 71 - 74
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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