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Effect of Central Cholinergic Stimulation on Regional Cerebral Blood Flow in Alzheimer's Disease

Published online by Cambridge University Press:  03 January 2018

Ken Wilson
Affiliation:
Department of Psychogeriatrics, Mossley Hill Hospital, Park Avenue, Liverpool L18 8BU
David Bowen
Affiliation:
Department of Neurochemistry, Institute of Neurology (Queen Square), 1 Wakefield Street, London WC1N 1PJ
Paul Francis
Affiliation:
Department of Neurochemistry, Institute of Neurology (Queen Square), 1 Wakefield Street, London WC1N 1PJ
Philippa Tyrrell
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London W12 OHS

Abstract

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

Type
The Current Literature
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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