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Effect of Anticholinergics on Tardive Dyskinesia

A Controlled Discontinuation Study

Published online by Cambridge University Press:  29 January 2018

W. Greil ,
H. Haag ,
G. Rossnagl  and
E. Rüther
W. Greil*
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstrasse 7, D-8000 Munich, Federal Republic of Germany
H. Haag
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstrasse 7, D-8000 Munich, Federal Republic of Germany
G. Rossnagl
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstrasse 7, D-8000 Munich, Federal Republic of Germany
E. Rüther
Affiliation:
Psychiatric Hospital of the University of Munich, Nussbaumstrasse 7, D-8000 Munich, Federal Republic of Germany
*
∗Correspondence
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Summary

In a double-blind, placebo-controlled study, ten chronic schizophrenic patients with pronounced symptoms of tardive dyskinesia (TD) were withdrawn from anticholinergic medication. All patients had previously been under long-term treatment with neuroleptics and anticholinergics for at least two years. The rating-scales used were the AIMS, our own TD Scale, and the Simpson-Angus scale for extra-pyramidal side-effects. The severity of TD decreased significantly in nine patients within two weeks; this improvement, most pronounced in the oral region (P <.001), persisted during a six-week placebo period. There was a slight increase in parkinsonian symptoms (P <.05), which was not a prerequisite for improvement in TD. Hence, discontinuation of anticholinergic medication is a possible therapeutic approach in patients with TD.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 3 , September 1984 , pp. 304 - 310
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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