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Early Neuroleptic Intervention in Schizophrenia: Are Prodromal Symptoms Valid Predictors of Relapse?

Published online by Cambridge University Press:  06 August 2018

W. Gaebel ,
U. Frick ,
W. Köpcke ,
M. Linden ,
P. Müller ,
F. Müller-Spahn ,
A. Pietzcker  and
J. Tegeler
W. Gaebel*
Affiliation:
Department of Psychiatry, Heinrich Heine University, Düsseldorf
U. Frick
Affiliation:
Biometric Centre for Therapy Studies, Munich
W. Köpcke
Affiliation:
Department of Informatics and Biomathematics, Wilhelms University, Münster
M. Linden
Affiliation:
Department of Psychiatry, Free University, Berlin
P. Müller
Affiliation:
Department of Psychiatry, Ludwig Maximilians University, Munich
F. Müller-Spahn
Affiliation:
Department of Psychiatry, Heinrich Heine University, Düsseldorf
A. Pietzcker
Affiliation:
Department of Psychiatry, Free University, Berlin
J. Tegeler
Affiliation:
Department of Psychiatry, Heinrich Heine University, Düsseldorf
*
∗Psychiatrische Klinik der Heinrich Heine Universität, Bergische Landstraße 2, D-40605 Düsseldorf, Germany
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Extract

All recently completed controlled two-year studies on intermittent, early neuroleptic intervention treatment have failed to compare favourably with studies on maintenance treatment concerning relapse prevention. The reason for this failure is still unclear. Therefore the implicit, but as yet unproven, hypothesis that a relapse can be predicted from prodromal symptoms was tested from the perspective of our German multicentre study. Results demonstrate that this is not the case. Possible reasons for and clinical implications of this negative finding are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue S21: Prediction in Psychopharmacology , September 1993 , pp. 8 - 12
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

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References

Carpenter, W. T., Stephens, J. H., Rey, A. C., et al (1982) Early intervention vs. continuous pharmacotherapy of schizophrenia. Psychopharmacology Bulletin, 18, 21–23.Google Scholar
Carpenter, W. T. & Heinrichs, D. W. (1983) Early intervention, time-limited, targeted pharmacotherapy of schizophrenia. Schizophrenia Bulletin, 9, 533–542.Google Scholar
Carpenter, W. T. & Heinrichs, D. W. & Hanlon, T. E. (1987) A comparative trial of pharmacologic strategies in schizophrenia. American Journal of Psychiatry, 144, 1466–1470.Google Scholar
Carpenter, W. T., Hanlon, T. E., Heinrichs, D. W., et al (1990) Continuous versus targeted medication in schizophrenic outpatients: outcome results. American Journal of Psychiatry, 147, 1138–1148.Google Scholar
Collegium Internationale Psychiatriae Scalarum (CIPS) (1981) Internationale Skalen für Psychiatrie. Weinheim: Beltz Test GmbH.Google Scholar
Davis, J. M., Schaffer, C. B., Killian, G. A., et al (1980) Important issues in the drug treatment of schizophrenia. Schizophrenia Bulletin, 6, 70–87.Google Scholar
Docherty, J. P., Van Kammen, D. P., Siris, S. G., et al (1978) Stages of onset of schizophrenic psychoses. American Journal of Psychiatry, 135, 420–426.Google Scholar
Donlon, P. T. & Blacker, K. H. (1973) Stages of schizophrenic decompensation and reintegration. Journal of Nervous and Mental Disease, 157, 200–209.Google Scholar
Endicott, J., Spitzer, R. L., Fleiss, J. L., et al (1976) The global assessment scale, a procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766–771.Google Scholar
Fava, G. A. & Kellner, R. (1991) Prodromal symptoms in affective disorders. American Journal of Psychiatry, 148, 823–830.Google Scholar
Herz, M. I. & Melville, Ch. (1980) Relapse in schizophrenia. American Journal of Psychiatry, 137, 801–805.Google Scholar
Herz, M. I., Szymanski, H. V. & Simon, J. C. (1982) Intermittent medication for stable schizophrenic outpatients: an alternative to maintenance medication. American Journal of Psychiatry, 139, 918–922.Google Scholar
Herz, M. I., Glazer, W. M., Mostert, M. A., et al (1991) Intermittent vs maintenance medication in schizophrenia: two-year results. Archives of General Psychiatry, 48, 333–339.Google Scholar
Hsiao, J. K., Bartko, J. J. & Potter, W. Z. (1989) Diagnosing diagnoses: receiver operating characteristic methods and psychiatry. Archives of General Psychiatry, 46, 664–667.Google Scholar
Jolley, A. G., Hirsch, S. R., Morrison, E., et al (1990) Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical and social outcome at two years. British Medical Journal, 301, 837–842.CrossRefGoogle ScholarPubMed
Marder, S. R., Mintz, J., Van Putten, T., et al (1991) Early prediction of relapse in schizophrenia: an application of Receiver Operating Characteristics (ROC) methods. Psychopharmacology Bulletin, 27, 79–82.Google Scholar
May, P. R. A. & Goldberg, S. C. (1978) Prediction of schizophrenic patients’ response to pharmacotherapy. In Psychopharmacology: A Generation of Progress (eds M. A. Lipton, K. F. DiMascio & K. F. Killam), pp. 1139–1153. New York: Raven Press.Google Scholar
Overall, J. E. & Gorham, D. R. (1962) The brief psychiatric rating scale. Psychological Reports, 10, 799–812.Google Scholar
Pietzcker, A. (1985) A German multicentre study on the long-term treatment of schizophrenic outpatients. Pharmacopsychiatry, 18, 333–338.CrossRefGoogle Scholar
Pietzcker, A., Gaebel, W., Kopcke, W., et al (1986) A German multicenter study on the neuroleptic long-term treatment of schizophrenic patients: preliminary report. Pharmacopsychiatry, 19, 161–166.CrossRefGoogle Scholar
Pietzcker, A., Gaebel, W., Kopcke, W., et al (1993) Continuous vs intermittent neuroleptic long-term treatment in schizophrenia - results of a German multicenter study. (Submitted for publication.)CrossRefGoogle Scholar
Schooler, N. R. (1991) Maintenance medication for schizophrenia: strategies for dose reduction. Schizophrenia Bulletin, 17, 311–324.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Tarrier, N., Barrowclough, C. & Bamrah, J. S. (1991) Prodromal signs of relapse in schizophrenia. Social Psychiatry, 26, 157–161.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Diseases (ICD-9). Geneva: WHO.Google Scholar
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