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A Double-blind Trial of Oxypertine for Anxiety Neurosis

Published online by Cambridge University Press:  29 January 2018

J. T. Robinson ,
L. S. Davies ,
Norman Kreitman  and
J. B. Knowles
J. T. Robinson
Affiliation:
Roffey Park Hospital, Horsham, Sussex
L. S. Davies
Affiliation:
Roffey Park Hospital, Horsham, Sussex
Norman Kreitman
Affiliation:
Medical Research Council Clinical Psychiatry Research Unit, Graylingwell Hospital, Chichester, Sussex
J. B. Knowles
Affiliation:
Medical Research Council Clinical Psychiatry Research Unit, Graylingwell Hospital, Chichester, Sussex
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Extract

Oxypertine is a new piperazine derivative, believed to have tranquillizing, antiadrenergic and hypotensive properties. Unpublished reports have suggested that it might be useful in chronic schizophrenia, although the recent study by Calwell et al. (1964) shows that its usefulness in this condition is limited. In view of its putative tranquillizing effect, the present clinical trial was undertaken to determine, under double-blind conditions, its efficacy as an adjunctive treatment for chronic anxiety neurosis. Ratings of anxiety symptoms were the major criteria for assessing the patients' progress, but the IPAT Anxiety Scale (Cattell and Scheier, 1957) was also included as a potentially useful measure of anxiety. An investigation of its validity was a subsidiary aim of the study.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 475 , June 1965 , pp. 527 - 529
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

Calwell, W. P. K., Jacobsen, M., and Skarbek, A. (1964). “A comparative study of oxypertine and trifluoperazine in chronic schizophrenia—a new application of the Wing Rating Scale.” Brit. J. Psychiat., 110, 520–530.Google Scholar
Cattell, R. B., and Scheier, I. H. (1957). The IPAT Anxiety Scale. Illinois: Champaign.Google Scholar
Eysenck, H. J. (1959). Manual of the Maudsley Personality Inventory. London.Google Scholar
Eysenck, H. J., and Eysenck, Sybil B.J. (1964). Manual of the Eysenck Personality Inventory. London.Google Scholar
Hamilton, M. (1959). “The assessment of anxiety states by rating.” Brit. J. med. Psychol., 32, 50–55.Google Scholar
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