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A Double-Blind Trial of Intravenous Thyrotrophin-Releasing Hormone in the Treatment of Reactive Depression

Published online by Cambridge University Press:  29 January 2018

L. E. J. Evans ,
P. Hunter ,
R. Hall ,
Moira Johnston  and
V. Mathew Roy
L. E. J. Evans
Affiliation:
Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP
P. Hunter
Affiliation:
Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP (Royal Salop Infirmary, Shrewsbury)
R. Hall
Affiliation:
University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LD
Moira Johnston
Affiliation:
Royal Victoria Infirmary, Newcastle upon Tyne
V. Mathew Roy
Affiliation:
Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP (Medical College Hospital, Trivandrum 11, Kerala, India)
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Summary

In a double-blind trial 600 μg. of thyrotrophin-releasing hormone (TRH) was compared with placebo given daily for four days to two groups of ten patients. There was no significant difference between the antidepressant effects of TRH and placebo.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 127 , Issue 3 , September 1975 , pp. 227 - 230
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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Footnotes

present address: St. Nicholas Hospital, Gosforth, Newcastle upon Tyne, NE3 3XT

References

Aitken, R. C. B. (1969) Measurement of feelings using visual analogue scales. Proceedings of the Royal Society of Medicine, 62, 989.Google Scholar
Coppen, A., Montgomery, S., Peet, M., Bailey, J., Marks, V. & Woods, P. (1974) Thyrotrophin-releasing hormone in the treatment of depression. Lancet, ii, 433.Google Scholar
Ehrensing, R. H., Kastin, A. J., Schlach, D. S., Friesen, H. G., Vargas, J. R. & Schally, A. V. (1974) Affective state and thyrotropin and prolactin responses after repeated injections of thyrotropin-releasing hormone in depressed patients. American Journal of Psychiatry, 131, 6, 714.CrossRefGoogle ScholarPubMed
Gurney, C. (1971) Diagnostic scales for affective disorders. Proceedings of the 5th World Congress of Psychiatry, Mexico City, p. 663.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Neurology, Neurosurgery and Psychiatry, 23, 56.Google Scholar
Kastin, A. J., Ehrensing, R. H., Schlach, D. S. & Anderson, M. S. (1972) Improvement in mental depression with decreased thyrotrophin response after administration of thyrotrophin-releasing hormone. Lancet, ii, 740.CrossRefGoogle Scholar
Mountjoy, C. Q., Price, J. S., Weller, M., Hunter, P., Hall, R. & Dewar, J. H. (1974) A double-blind crossover sequential trial of oral thyrotrophin-releasing hormone in depression. Lancet, i, 958.Google Scholar
Prange, A. J. Jr., Wilson, I. C., Lara, P. P., Alltop, L. B., & Breese, G. R. (1972) Effects of thyrotrophin-releasing hormone in depression. Lancet, ii, 999.Google Scholar
Snaith, R. P., Ahmed, S. N., Mehta, S. & Hamilton, M. (1971) Assessment of the severity of primary depressive illness. Psychological Medicine, 1, 143.CrossRefGoogle ScholarPubMed
Van der Vis-Melsen, M. J. E., & Weiner, J. D. (1974) Improvement in mental depression with decreased thyrotrophin response after administration of thyrotrophin-releasing hormone. Lancet, ii, 1415.Google Scholar
Zeally, A. K. & Aitken, R. C. B. (1969) Measurement of mood. Proceedings of the Royal Society of Medicine, 62, 993.Google Scholar
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