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A Double-blind Comparative Trial of Moclobemide v. Imipramine and Placebo in Major Depressive Episodes

Published online by Cambridge University Press:  06 August 2018

M. Versiani ,
U. Oggero ,
P. Alterwain ,
R. Capponi ,
F. Dajas ,
G. Heinze-Martin ,
C.A. Marquez ,
M.A. Poleo ,
L.E. Rivero-Almanzor  and
L. Rossel
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M. Versiani
Affiliation:
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, Brazil
U. Oggero
Affiliation:
Juiz de Forta — MG, Brazil
P. Alterwain
Affiliation:
Br. Artigas, Montevideo, Uruguay
R. Capponi
Affiliation:
Hospital Sanatorio El Peral Psiquiatria, Santiago de Chile, Chile
F. Dajas
Affiliation:
Neurochemistry Division, Instituto de investigaciones biologicas clemente estable, Montevideo, Uruguay
G. Heinze-Martin
Affiliation:
Hospital General Adolfo Lopez Mateos, Mexico
C.A. Marquez
Affiliation:
Instituto Privado de Psicopatologia, Buenos Aires, Argentina
M.A. Poleo
Affiliation:
Los Palos Grandes, Caracas, Venezuela
L.E. Rivero-Almanzor
Affiliation:
Hospital Psiquiatrico San Juan de Dios, Mexico City, Mexico
L. Rossel
Affiliation:
Centro Cientifico de Desarrollo Psicologico, Santiago de Chile, Chile
W. Schmid-Burgk
Affiliation:
F. Hoffmann-La Roche Ltd, Basel, Switzerland
R. Ucha-Udabe
Affiliation:
Instituto Privado de Psicopatologia, Buenos Aires, Argentina
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Abstract

Patients (n = 490) suffering from a major depressive episode according to DSM-III criteria were randomly allocated to groups receiving either moclobemide, imipramine, or placebo treatment. Subjects were treated as out-patients for 6 weeks. On overall assessment of efficacy and on results of the Hamilton Rating Scale for Depression, both moclobemide and imipramine were superior to placebo, but the differences between moclobemide and imipramine were not significant. Premature termination due to insufficient efficacy was more frequent with placebo than with moclobemide or with imipramine, these differences being significant. The overall assessment of tolerance clearly favoured placebo and moclobemide over imipramine. This was also reflected in the frequency of premature terminations due to poor tolerance, as well as in the frequency of adverse events, which were highest in the imipramine group. The only cardiovascular finding was an increase of the mean heart rate with imipramine, maximum at the end of week 1, while placebo and moclobemide displayed no relevant changes. There were no other important drug-related changes.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 155 , Issue S6: Depression and Reversible Monoamine Oxidase Inhibitors-New Perspectives , October 1989 , pp. 72 - 77
Copyright
Copyright © 1989 The Royal College of Psychiatrists 

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