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The Dopamine Hypothesis Survives, but There Must Be a Way Ahead

Published online by Cambridge University Press:  02 January 2018

T. J. Crow
T. J. Crow*
Affiliation:
Clinical Research Centre, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ
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Extract

Karl Popper has taught us that no hypothesis can be regarded as proved-merely as having survived the most stringent tests which have so far been devised. Dinan makes a further attempt to overthrow the dopamine hypothesis of the mechanism of the antipsychotic effect, and provides an alternative suggestion. As one time critic and later advocate of the theory, I think he underestimates its explanatory power and capacity for survival. I doubt that his alternative yet poses a serious challenge. I propose below a second (and perhaps more idiosyncratic) alternative. I do not claim it yet has the explanatory power of the dopamine theory, but I think it generates some new approaches.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 4 , October 1987 , pp. 460 - 465
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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