Hostname: page-component-848d4c4894-nmvwc Total loading time: 0 Render date: 2024-07-01T01:20:12.900Z Has data issue: false hasContentIssue false
  • English
  • Français

The Dexamethasone Suppression Test in Generalised Anxiety Disorder

Published online by Cambridge University Press:  29 January 2018

Edward E. Schweizer ,
Charlotte M. Swenson ,
Andrew Winokur ,
Karl Rickels  and
Greg Maislin
Edward E. Schweizer*
Affiliation:
Department of Psychiatry, University of Pennsylvania, 203 Piersol Building, 3400 Spruce Street, Philadelphia, Pennsylvania 19104
Charlotte M. Swenson
Affiliation:
Department of Psychiatry, University of Pennsylvania, 203 Piersol Building, 3400 Spruce Street, Philadelphia, Pennsylvania 19104
Andrew Winokur
Affiliation:
Department of Psychiatry, University of Pennsylvania, 203 Piersol Building, 3400 Spruce Street, Philadelphia, Pennsylvania 19104
Karl Rickels
Affiliation:
University of Pennsylvania, 203 Piersol Building, 3400 Spruce Street, Philadelphia, Pennsylvania 19104
Greg Maislin
Affiliation:
Department of Statistics, University of Pennsylvania, 203 Piersol Building, 3400 Spruce Street, Philadelphia, Pennsylvania 19104
*
Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

The dexamethasone suppression test was performed on 79 patients with a diagnosis of generalised anxiety disorder. A non-suppression rate of 27% was obtained, comparable to that found in out-patient major depression but notably higher than previous reports in panic disorder. No good clinical predictors of non-suppression were discovered, nor was the co-occurrence of depression sufficient to account for the finding.

Type
Papers
Information
The British Journal of Psychiatry , Volume 149 , Issue 3 , September 1986 , pp. 320 - 322
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Amsterdam, J. D., Winokur, A., Caroff, S. N. & Conn, J. (1982) The dexamethasone suppression test in outpatients with primary affective disorder and healthy control subjects. American Journal of Psychiatry, 130, 287–291.Google Scholar
Carroll, B. J. (1982) The dexamethasone suppression test for melancholia. British Journal of Psychiatry, 140, 292–304.Google Scholar
Feinberg, M., Greden, J. F., Tarika, J., Albala, A. A., Haskett, R. F., James, N. M., Kroupol, Z., Lohr, N. & Steiner, M. (1981) A specific laboratory test for the diagnosis of melancholia. Archives of General Psychiatry, 38, 15–22.Google Scholar
Castro, P., Lemaine, M., Toscano-Aguilar, M., Toscanoa, M. & Herchuela, A. (1983) Abnormal DST results in patients with chronic schizophrenia. American Journal of Psychiatry, 140, 1261.CrossRefGoogle ScholarPubMed
Coppen, A., Abou-Saleh, M., Millu, P., Metcalfe, M., Harwood, J. & Bailey, J. (1983) Dexamthasone suppression test in depression and other psychiatric illness. British Journal of Psychiatry, 142, 498–504.Google Scholar
Crowe, R. R., Noyes, R., Pauls, D. L. & Slymen, D. (1983) A family study of panic disorder. Archives of General Psychiatry, 40, 1065–1069.Google Scholar
Curtis, G. C., Cameron, O. G. & Nesse, R. M. (1982) The dexamethasone suppression test in panic disorder and agoraphobia. American Journal of Psychiatry, 139, 1043–1046.Google Scholar
Dewan, M. J., Pandurangi, A. K., Boucher, M. L., Levy, B. F. & Major, L. F. (1982) Abnormal dexamethasone suppression test results in chronic schizophrenic patients. American Journal of Psychiatry, 139, 1501–1503.Google ScholarPubMed
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837–844.CrossRefGoogle ScholarPubMed
Feighner, J. P., Aden, G. C., Fabre, L. F., Rickels, K. & Smith, W. T. (1983) Comparison of alprazolam, Imipramine, and placebo in the treatment of depression. Journal of the American Medical Association, 249, 3057–3064.CrossRefGoogle ScholarPubMed
Hallstrom, T., Samuelsson, S., Balldin, J., Walinder, J., Bengtsson, C., Nystrom, E., Andersch, B., Lindstedt, G. & Lundberg, P. A. (1983) Abnormal dexamethasone suppression test in normal females. British Journal of Psychiatry, 142, 489–497.Google Scholar
Klein, D. F. (1984) Psychopharmacologic treatment of panic disorder. Psychosomatics Supplement, 25, 32–36.CrossRefGoogle ScholarPubMed
Leckman, J. F., Weissman, M. M., Merikangas, K. R., Pauls, D. L. & Prusoff, B. A. (1983) Panic disorder and major depression. Archives of General Psychiatry, 40, 1055–1060.CrossRefGoogle ScholarPubMed
Lieberman, J. A., Brenner, R., Lesser, M., Coccaro, E., Borenstein, M. & Kane, J. M. (1983) Dexamethasone suppression tests in patients with panic disorder. American Journal of Psychiatry, 140, 917–919.Google Scholar
Rabkin, J. G., Quitkin, F. M., Stewart, J. W., McGrath, P. J. & Puig-Antich, J. (1983) The dexamethasone suppression test with mildly to moderately depressed outpatients. American Journal of Psychiatry, 140, 926–927.Google Scholar
Raskind, M., Peskind, E., Rivard, M. F., Veith, R. & Barnes, R. (1982) Dexamethasone suppression test and Cortisol circadian rhythm in primary degenerative dementia. American Journal of Psychiatry, 139, 1468–1471.Google Scholar
Sheehan, D., Ballenger, J. & Jacobsen, G. (1980) Treatment of endogenous anxiety with phobic hysterical and hypochrondriacal symptoms. Archives of General Psychiatry, 37, 51–59.CrossRefGoogle Scholar
Sheehan, D. V., Claycomb, J. B., Surman, O. S., Baer, L. Coleman, J. & Gelles, L. (1983) Panic attacks and the dexamethasone suppression test. American Journal of Psychiatry, 140, 1063–1064.Google Scholar
Targum, S. D. (1983) Neuroendocrine dysfunction in schizophreniform disorder. American Journal of Psychiatry, 140, 309–313.Google Scholar
Winokur, A., Amsterdam, J., Caroff, S., Snyder, P. J. & Brunswick, D. (1982) Variability of hormonal responses to a series of neuroendocrine challenges in depressed patients. American Journal of Psychiatry, 139, 39–44.Google ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.