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Depressive Classification and Prediction of Response to Phenelzine

Published online by Cambridge University Press:  29 January 2018

E. S. Paykel ,
R. R. Parker ,
R. J. J. Penrose  and
E. R. Rassaby
E. S. Paykel
Affiliation:
St George's Hospital Medical School, London SW17
R. R. Parker
Affiliation:
King's College Hospital, Formerly Research Fellow, St George's Hospital Medical School
R. J. J. Penrose
Affiliation:
West Park Hospital, Epsom, Surrey
E. R. Rassaby
Affiliation:
St George's Hospital Medical School
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Summary

A variety of depressive classifications were used to predict response to four weeks' treatment with phenelzine. Better response was found in outpatients rather than inpatients, in atypical depressives, in less severe depressives with a pattern of anxiety and other neurotic symptoms, and in groups characterized as hostile and agitated. The findings, although a little patchy, gave clear support to the concept of a specific clinical group responsive to MAO inhibitors.

Type
Papers
Information
The British Journal of Psychiatry , Volume 134 , Issue 6 , June 1979 , pp. 572 - 581
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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References

Bielski, R. J. & Friedel, R. O. (1976) Prediction of tricyclic antidepressant response. A critical review. Archives of General Psychiatry, 33, 1479–89.CrossRefGoogle ScholarPubMed
Blalock, H. M. (1972) Social Statistics (Second Edition). New York: McGraw Hill.Google Scholar
Covi, L., Lipman, R. S., Derogatis, R., Smith, J. E. & Pattison, J. H. (1974) Drugs and group psychotherapy in neurotic depression. American Journal of Psychiatry, 131, 191–8.CrossRefGoogle ScholarPubMed
Dally, P. J. & Rohde, P. (1961) Comparison of antidepressant drugs in depressive illness. Lancet, i, 18.CrossRefGoogle Scholar
Friedman, A. S. (1975) Interaction of drug therapy with mental therapy in depressive patients. Archives of General Psychiatry, 32, 619–37.CrossRefGoogle Scholar
Greenblatt, M., Grosser, G. H. & Wechsler, H. (1964) Differential response of hospitalized depressed patients to somatic therapy. American Journal of Psychiatry, 120, 935–43.CrossRefGoogle ScholarPubMed
Hollister, L. E., Overall, J. E., Johnson, M. H., Shelton, J., Kimbell, I. & Brunse, A. (1966) Amitriptyline alone and combined with perphenazine in newly admitted depressed patients. Journal of Nervous and Mental Disease, 142, 460–9.CrossRefGoogle ScholarPubMed
Hollister, L. E., Overall, J. E., Shelton, J., Pennington, V., Kimbell, I. & Johnson, M. H. (1967) Drug therapy of depression. Amitriptyline, perphenazine and their combination in different syndromes. Archives of General Psychiatry, 17, 486–93.CrossRefGoogle ScholarPubMed
Kay, D. W. K., Garside, R. F. & Fahy, T. J. (1973) A double-blind trial of phenelzine and amitriptyline in depressed outpatients. A possible differential effect of the drugs on symptoms. British Journal of Psychiatry, 123, 63–7.CrossRefGoogle ScholarPubMed
Kelly, D., Guirguis, W., Frommer, E., Mitchell-Heggs, N. & Sargant, W. (1970) Treatment of phobic states with antidepressants. A retrospective study of 164 patients. British Journal of Psychiatry, 116, 387–98.CrossRefGoogle Scholar
Kendell, R. E. (1976) The classification of depressions: a review of contemporary confusion. British Journal of Psychiatry, 129, 15–28.CrossRefGoogle ScholarPubMed
Lipsedge, B. S., Hajioff, J., Huggins, P., Napier, L., Pearce, J., Pike, D. J. & Rich, M. (1973) The management of severe agoraphobia: a comparison of iproniazid and systematic desensitization. Psychopharmacologia, 32, 67–80.CrossRefGoogle ScholarPubMed
Medical Research Council (1965) Clinical trial of the treatment of depressive illness. British Medical Journal, 1, 881–6.Google Scholar
Middlefell, R., Frost, I., Egan, G. P. & Eaton, H. (1960) A report on the effects of phenelzine (Nardil), a monoamine oxidase inhibitor, in depressed patients. Journal of Mental Science, 106, 1533–1538.CrossRefGoogle ScholarPubMed
Office of Population, Censuses and Surveys (1968) The English Glossary of the International Classification of Disease. London: H.M. Stationery Office.Google Scholar
Overall, J. E. & Goreham, D. R. (1962) The brief psychiatric rating scale. Psychological Reports, 10, 799–812.CrossRefGoogle Scholar
Overall, J. E., Hollister, L. E., Johnson, M. H. & Pennington, V. (1966) Nosology of depression and differential response to drugs. Journal of the American Medical Association, 195, 946–8.Google ScholarPubMed
Overall, J. E., Hollister, L. E., Pokorny, A. D., Casey, J. F. & Katz, G. (1962) Drug therapy in depressions. Controlled evaluation of imipramine, isocarboxazid, dextroamphetamine-amobarbital, and placebo. Clinical Pharmacology and Therapeutics 3, 16–22.CrossRefGoogle ScholarPubMed
Pare, C. M. B. (1977) Monoamine oxidase inhibitors: a personal account. In Burrows, G. (Ed.). A Handbook of Studies on Depression. Amsterdam: Excerpta Medica.Google Scholar
Pare, C. M. B. & Sandler, M. (1959) A clinical and biochemical study of a trial of iproniazid in the treatment of depression. Journal of Neurology, Neurosurgery and Psychiatry, 22, 247–51.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1971) Classification of depressed patients: a cluster analysis derived grouping. British Journal of Psychiatry, 118, 175–288.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1972) Depressive typologies and response to amitriptyline. British Journal of Psychiatry, 120, 147–56.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1979) Predictors of treatment response. In Paykel, E. S. and Coppen, A. (Eds.). Psychopharmacology of Affective Disorders. London: Oxford University Press.Google Scholar
Paykel, E. S. & Rassaby, E. (1979 in press) Factor patterns in depression: a replication study. Journal of Affective Disorders. Google Scholar
Paykel, E. S., Klerman, G. L. & Prusoff, B. A. (1970) Treatment setting and clinical depression. Archives of General Psychiatry, 22, 11–21.CrossRefGoogle ScholarPubMed
Paykel, E. S., Prusoff, B. A. & Klerman, G. L. (1971) The endogenous-neurotic continuum in depression: rater independence and factor distributions. Journal of Psychiatric Research, 8, 73–90.CrossRefGoogle ScholarPubMed
Paykel, E. S., Prusoff, B. A., Klerman, G. L., Haskell, D. & DiMascio, A. (1973) Clinical response to amitriptyline among depressed women. Journal of Nervous and Mental Disease, 156, 149–65.CrossRefGoogle ScholarPubMed
Pollitt, J. (1965) Depression and its Treatment. London: Heinemann.Google Scholar
Prusoff, B. A. & Paykel, E. S. (1977) Typological prediction of response to amitriptyline: a replication study. International Pharmacopsychiatry, 12, 153–9.CrossRefGoogle ScholarPubMed
Raskin, A., Schulterbrandt, J. G., Reatig, N., Crook, T. H. & Odle, D. (1974) Depression subtypes and response to phenelzine, diazepam and a placebo. Archives of General Psychiatry, 30, 66–75.CrossRefGoogle ScholarPubMed
Raskin, A., Schulterbrandt, J. G., Reatig, N. & McKeon, J. (1970) Differential response to chlorpromazine, imipramine and placebo. A study of subgroups of hospitalized depressed patients. Archives of General Psychiatry, 23, 164–73.CrossRefGoogle ScholarPubMed
Robinson, D. S., Nies, A., Ravaris, C. L., Ives, J. O. & Lamborn, K. R. (1974) Treatment response to MAO inhibitors: relation to depressive typology and blood platelet inhibition. In Angst, J. (Ed.) Classification and Prediction of Outcome of Depression. Stuttgart: F. K. Schattauer Verlag.Google Scholar
Rogers, S. C. & Clay, P. M. (1975) A statistical review of controlled trials of imipramine and placebo in the treatment of depressive illnesses. British Journal of Psychiatry, 127, 599–603.CrossRefGoogle ScholarPubMed
Sargant, W. (1961) Drugs in the treatment of depression. British Medical Journal, i, 225–7.Google Scholar
Sargant, W. & Dally, P. (1962) Treatment of anxiety states by antidepressant drugs. British Medical Journal, i, 5–9.Google Scholar
Solyom, L., Heseltine, G. F. D., McClure, D. J., Ledwidge, B. & Steinberg, G. (1973) Behaviour therapy versus drug therapy in the treatment of phobic neurosis. Canadian Psychiatric Association Journal, 18, 25–31.CrossRefGoogle ScholarPubMed
Tyrer, P. (1976) Towards rational therapy with monoamine oxidase inhibitors. British Journal of Psychiatry, 128, 354–60.CrossRefGoogle ScholarPubMed
Tyrer, P., Candy, J. & Kelly, D. (1973) Phenelzine in phobic anxiety: a controlled trial. Psychological Medicine, 3, 120–4.CrossRefGoogle ScholarPubMed
Uhlenhuth, E. H. & Park, L. C. (1964) The influence of medication (imipramine) and doctor in relieving depressed psychoneurotic patients. Journal of Psychiatric Research, 2, 101–22.CrossRefGoogle Scholar
West, E. D. & Dally, P. J. (1959) Effects of iproniazid in depressive syndromes. British Medical Journal, i, 1491–4.Google Scholar
Wittenborn, J. R., Plante, M., Burgess, F. & Maurer, H. (1962) A comparison of imipramine, ECT and placebo in the treatment of depression. Journal of Nervous and Mental Disease, 135, 131–7.CrossRefGoogle Scholar
Zitrin, C. M., Klein, D. F., Lindemann, C., Tobak, P., Rock, M. M., Kaplan, J. H. & Ganz, V. H. (1976) Comparison of short-term treatment regimens in phobic patients: a preliminary report. In Spitzer, R. and Klein, D. F. (Eds.) Evaluation of Psychological Therapies. Baltimore: Johns Hopkins University Press.Google Scholar
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