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Depressive and Extrapyramidal Symptoms and Clinical Effects: A Trial of Fluphenazine versus Flupenthixol in Maintenance of Schizophrenic Out-patients

Published online by Cambridge University Press:  29 January 2018

Angela Knights ,
M. S. Okasha ,
Mohamed Ali Salih  and
S. R. Hirsch
Angela Knights
Affiliation:
Department of Psychiatry, Charing Cross Hospital, London W6 8RF
M. S. Okasha
Affiliation:
12 Case Street, Norwich, Connecticut 06360. Tale University School of Medicine
Mohamed Ali Salih
Affiliation:
Whitecroft Hospital, Isle of Wight
S. R. Hirsch
Affiliation:
Department of Psychiatry, Charing Cross Hospital, London W6 8RF
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Summary

Fifty-seven patients with a diagnosis of schizophrenia were started on either fluphenazine decanoate or flupenthixol decanoate injections in a double-blind trial just prior to discharge into the community. During the six month follow-up 30 per cent dropped out of the treatment. Of those observed for six months, 7 per cent relapsed, 54 per cent experienced depressive symptoms and 88 per cent extrapyramidal side-effects. Analysis of both clinical data and the ratings failed to discriminate between the two drugs.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 135 , Issue 6 , December 1979 , pp. 515 - 523
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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