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Depression Influences Intellectual Impairment in Stroke Patients

Published online by Cambridge University Press:  29 January 2018

Robert G. Robinson ,
Karen Bolla-Wilson ,
Edith Kaplan ,
John R. Lipsey  and
Thomas R. Price
Robert G. Robinson*
Affiliation:
Departments of Psychiatry and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Karen Bolla-Wilson
Affiliation:
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine
Edith Kaplan
Affiliation:
Psychology Service, VAMC and Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02130, USA
John R. Lipsey
Affiliation:
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine
Thomas R. Price
Affiliation:
Department of Neurology, University of Maryland School of Medicine
*
∗Correspondence
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Abstract

Patients with ischaemic lesions of the left cerebral hemisphere were examined for depression and intellectual impairment: in non-depressed patients, the severity of impairment was related to both lesion volume and location, as assessed by CT scan analysis. Cognitive impairment in patients with major depression was greater than predicted by lesion volume alone, and when patients were matched for severity of impairment, depressed patients had smaller lesion volumes than the non-depressed. After six months, non-depressed patients had significantly less cognitive impairment than depressed patients who showed no improvement. Both depression and lesion volume were significantly and independently related to cognitive impairment. These findings suggest that post-stroke depression can produce a true dementia in Its own right, and that treatment of post-stroke depression might benefit cognitive function.

Type
Papers
Information
The British Journal of Psychiatry , Volume 148 , Issue 5 , May 1986 , pp. 541 - 547
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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