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Decreased Urinary Output of Tyramine and its Metabolites in Depression

Published online by Cambridge University Press:  29 January 2018

Susan Bonham Carter ,
M. Sandler ,
B. L. Goodwin ,
P. Sepping  and
P. K. Bridges
Susan Bonham Carter
Affiliation:
Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London W6 0XG
M. Sandler
Affiliation:
Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London W6 0XG
B. L. Goodwin
Affiliation:
Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London W6 0XG
P. Sepping
Affiliation:
The Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London SE18 4LW
P. K. Bridges
Affiliation:
The Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London SE18 4LW
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Summary

Despite dramatic clinical improvement in about one-third of a group of severely depressed, medication-resistant patients one year after modified leucotomy, their relative decrease in conjugated and free tyramine output after an oral tyramine load remained unchanged and abnormal. Whilst a direct deficit in intestinal tyramine-conjugating ability still needs to be finally ruled out, this appears most compatible with a deficit due to bodily metabolic failure, perhaps a deficit in membrane transport which could be an essential aspect of the depressive illness syndrome. Attention is drawn to a similar defect in migraine. The two illnesses may represent a common predisposition which an appropriate triggering mechanism may transform to the florid disease. Biochemical detection of such vulnerability may have important diagnostic and predictive significance.

Type
Papers
Information
The British Journal of Psychiatry , Volume 132 , Issue 2 , February 1978 , pp. 125 - 132
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Anthony, M. & Lance, J. W. (1969) Monoamine oxidase inhibition in the treatment of migraine. Archives of Neurology, 21, 263–8.Google Scholar
Baldessarini, R. J. (1975) The basis for amine hypotheses in affective disorders. A critical evaluation. Archives of General Psychiatry, 32, 1087–93.Google Scholar
Bonham Carter, S., Sandler, M., Sepping, P. & Bridges, P. K. (1977) Decreased conjugated tyramine output in depression: gastrointestinal factors. British Journal of Clinical Pharmacology. In press.Google Scholar
Boulton, A. A. & Milward, L. (1971) Separation, detection and quantitative analysis of urinary β-phenylethylamine. Journal of Chromatography, 57, 287–96.Google Scholar
Christensen, H. N. (1975) Biological Transport, 2nd Edn. Reading, Mass.: Benjamin.Google Scholar
Coppen, A., Brooksbank, B. W. L., Eccleston, E., Peet, M. & White, S. G. (1974) Tryptophan metabolism in depressive illness. Psychological Medicine, 4, 164–73.Google Scholar
Coppen, A. & Ghose, K. (1977) Personal communication.Google Scholar
Coppen, A. Shaw, D. M., Malleson, A., Eccleston, E. & Gundy, G. (1965) Tryptamine metabolism in depression. British Journal of Psychiatry, 111, 993–8.Google Scholar
Couch, J. R., Ziegler, D. K. & Hassanein, R. (1975) Evaluation of the relationship between migraine, headache and depression. Headache, 15, 41–50.Google Scholar
Ekbom, K. (1974) Litium vid kroniska symptom av cluster headache. Opuscula Medica, 19, 148–56.Google Scholar
Fischer, E., Heller, B. & Miro, A. N. (1968) β-Phenylethylamine in human urine. Arzneimittel Forschung, 18, 1486.Google Scholar
Ghose, K., Coppen, A. & Carroll, D. (1977) Intravenous tyramine response in migraine before and during treatment with indoramin. British Medical Journal, i, 1191–3.Google Scholar
Ghose, K. Turner, P. & Coppen, A. (1975) Intravenous tyramine pressor response in depression. Lancet, i, 1317–18.Google Scholar
Gillis, C. N. & Roth, J. A. (1977) The fate of biogenic monoamines in perfused rabbit lung. British Journal of Pharmacology, 59, 585–90.Google Scholar
Göktepe, E. O., Young, L. B. & Bridges, P. K. (1975) A further review of the results of stereotactic subcaudate tractotomy. British Journal of Psychiatry, 126, 270–80.Google Scholar
Gomersall, J. D. & Stuart, A. (1973) Amitriptyline in migraine prophylaxis. Journal of Neurology, Neurosurgery and Psychiatry, 36, 684–90.Google Scholar
Goodwin, B. L., Ruthven, C. R. J., Fellows, L. E. & Sandler, M. (1976) A specific method for the recovery of aromatic acids from biological fluids. Clinica Chimica Acta, 73, 191–7.Google Scholar
Goodwin, B. L., Ruthven, C. R. J. & Sandler, M. (1974) Gas chromatographic estimation of urinary homovanillic and 4-hydroxy-3-methoxymandelic acids using capillary columns. Clinica Chimica Acta, 55, 111–12.Google Scholar
Goodwin, B. L. & Sandler, M. (1975) Improved resolution using capillary columns. Clinica Chimica Acta, 59, 253–4.Google Scholar
Hengstmann, J. A., Konen, W., Konen, C., Eichelbaum, M. & Dengler, H. J. (1975) Bioavailability of m-octopamine in man related to its metabolism. European Journal of Clinical Pharmacology, 8, 33–9.Google Scholar
Jenner, W. N. & Rose, F. A. (1973) Studies on the sulphation of 3,4-dihydroxyphenylethylamine (dopamine) and related compounds by rat tissues. Biochemical Journal, 135, 109–14.Google Scholar
Kendell, R. E. (1976) The classification of depressions: a review of contemporary confusion. British Journal of Psychiatry, 129, 15–28.Google Scholar
Kendell, R. E. Wainwright, S., Hailey, A. & Shannon, B. (1976) The influence of childbirth on psychiatric morbidity. Psychological Medicine, 6, 297–302.Google Scholar
Knight, G. (1965) Stereotactic tractomy in the surgical treatment of mental illness. Journal of Neurology, Neurosurgery and Psychiatry, 28, 304–10.Google Scholar
Maas, J. W., Fawcett, J. & Dekirmenjian, H. (1968) 3-Methoxy-4-hydroxyphenylglycol (MHPG) excretion in depressive states. Archives of General Psychiatry, 19, 129–34.Google Scholar
Mannarino, E., Kirshner, N. & Nashold, B. S. Jr (1963) The metabolism of [14C]-noradrenaline by cat brain in vivo. Journal of Neurochemistry, 10, 373–9.Google Scholar
McCowan, P. K. & Quastel, J. H. (1931) Blood sugar studies in abnormal mental states. Journal of Mental Science, 77, 525–48.Google Scholar
Mendels, J. & Frazer, A. (1974) Alterations in cell membrane activity in depression. American Journal of Psychiatry, 131, 1240–6.Google Scholar
Morgan, C. D., Ruthven, C. R. J. & Sandler, M. (1969) The quantitative assessment of isoprenaline metabolism in man. Clinica Chimica Acta, 26, 381–6.Google Scholar
Mueller, P. S., Heninger, G. R. & McDonald, R. K. (1969) Intravenous glucose tolerance test in depression. Archives of General Psychiatry, 21, 470–7.Google Scholar
Pitt, B. (1975) Psychiatric illness following childbirth. British Journal of Psychiatry, Special No. 9, 409–15.Google Scholar
Rafaelsen, O. J. (1974) Manic-depressive psychosis or manic-melancholic mode. Danish Medical Bulletin, 21, 81–7.Google Scholar
Sandler, M., Bonham Carter, S., Cuthbert, M. F. & Pare, C. M. B. (1975) Is there an increase in monoamine oxidase activity in depressive illness? Lancet, i, 1045–9.Google Scholar
Sandler, M., Ruthven, C. R. J. & Caesar, P. M. (1967) Urinary pH and the excretion of biologically active monoamines and their acidic metabolites. Proceedings of the 7th International Congress of Biochemistry, Tokyo, p 971.Google Scholar
Schildkraut, J. J. (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. American Journal of Psychiatry, 122, 509–522.Google Scholar
Seixas, F. A. (ed.) (1977) Currents in Alcoholism, Vol. 2, Psychiatric, Psychological, Social and Epidemiological Studies. New York: Grune and Stratton.Google Scholar
Smith, I. & Mitchell, P. D. (1974) The effect of oral inorganic sulphate on the metabolism of 4-hydroxyphenylethylamine (tyramine) in man: tyramine-O-sulphate measurement in human urine. Biochemical Journal, 142, 189–91.Google Scholar
Smith, S. M. (1973) The Battered Child Syndrome. London: Butterworth.Google Scholar
Tuomisto, J. & Tukiainen, E. (1976) Decreased uptake of 5-hydroxytryptamine in blood patelets from depressed patients. Nature, 262, 596–8.Google Scholar
Wolstenholme, G. E. W. & Knight, J. (eds) (1976) Monoamine Oxidase and its Inhibition. Amsterdam: Elsevier-Excerpta Medical—North Holland.Google Scholar
Youdim, M. B. H., Bonham Carter, S., Sandler, M., Hanington, E. & Wilkinson, M. (1971) Conjugation defect in tyramine-sensitive migraine. Nature, 230, 127–8.Google Scholar
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