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Decarboxylation of Radioactive DOPA by Erythrocytes in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Ngo Tran ,
Marcel Laplante  and
Etienne Lebel
Ngo Tran
Affiliation:
Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada
Marcel Laplante
Affiliation:
Centre Hospitalier Universitairey Sherbrooke, Quebec, Canada
Etienne Lebel
Affiliation:
Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada
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Extract

The decarboxylation of 3, 4-dihydroxyphenyl-alanine (Dopa) to dopamine has been shown previously in animal and human tissues in both in vitro and in vivo studies (Sourkes, 1966; Vogel et al., 1970). However, very little information is available as to whether or not the decarboxylation of Dopa occurs in human red blood cells (RBC). In the present experiment we demonstrated this change in RBC from normals and from schizophrenics. An ionization chamber method was used for an instantaneous and continuous measurement of 14CO2 production from DL-dopa-carboxyl-14C by RBC in vitro.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 118 , Issue 545 , April 1971 , pp. 465 - 466
Copyright
Copyright © Royal College of Psychiatrists, 1971 

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References

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