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A Danish Twin Study of Manic-Depressive Disorders

Published online by Cambridge University Press:  29 January 2018

A. Bertelsen ,
B. Harvald  and
M. Hauge
A. Bertelsen
Affiliation:
University of Aarhus, Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, 8240 Risskov, Denmark
B. Harvald
Affiliation:
Department of Medicine, University of Odense, 5000 Odense, Denmark
M. Hauge
Affiliation:
The Danish Twin Register, Institute of Medical Genetics, University of Odense, 5000 Odense, Denmark
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Summary

The existence of a nation-wide twin register and central psychiatric register has made possible a catamnestic investigation of an unselected and representative sample of twins with manic-depressive disorders.

From a total population of 11,288 same-sexed twin pairs born 1870–1920 in Denmark 126 probands from no pairs were ascertained. Among the co-twins of 69 monozygotic probands there were found 46 with manic-depressive disorders, and a further 14 had presented other psychoses or marked affective personality disorders or had committed suicide, yielding a proband rate of strict concordance, C1 = 0·67 and of broad, partial concordance, C2 = 0·87. The corresponding direct pairwise concordance rates were 32/55 = 0·58 and 46/55 = 0·84 respectively. For the dizygotic twins the proband concordance rate of C1 was 11/54 = 0·20 and of C2 20/54 = 0·37, and the direct pairwise rates were 9/52 = 0·17 and 18/52 = 0·35 respectively. The differences between the pairwise rates for the monozygotic and dizygotic twins are significant (P < 0·001 at χ2 analysis). This finding is in accordance with previous twin studies of manic-depressive disorders and confirms the evidence of a strong genetic factor. The concordance with respect to unipolar and bipolar forms was not in contradiction to recent evidence of a genetic difference between the bipolar and unipolar form, the latter probably related to the female sex.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 4 , April 1977 , pp. 330 - 351
Copyright
Copyright © Royal College of Psychiatrists, 1977 

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References

Allen, G., Harvald, B. & Shields, J. (1967) Measures of twin concordance. Acta Genetica et Statistica Medica, 17, 475–81.Google Scholar
Allen, M. G., Cohen, S., Pollin, W. & Greenspan, S. I. (1974) Affective illness in veteran twins. A diagnostic review. American Journal of Psychiatry, 131, 1234–9.Google ScholarPubMed
Angst, J. (1966) Zur Ätiologie und Nosologie endogener depressiven Psychosen. Monographien aus dem Gesamtgebiete der Neurologie und Psychiatric, Heft 112. Berlin: Springer.CrossRefGoogle Scholar
Dupont, A., Videbech, Th. & Weeke, A. (1974) A cumulative national psychiatric register: Its structure and application. Acta Psychiatrica Scandinavica, 50, 161–73.Google Scholar
Essen-Möller, E. (1941) Psychiatrische Untersuchungen an einer Serie von Zwillingen. Copenhagen: Munksgaard.Google Scholar
Da Fonseca, A. F. (1959) Análise Heredo-clínica das Perturbanções Afectivas. Oporto (cited by Zerbin-Rüdin, 1969).Google Scholar
Fischer, M. (1973) Genetic and Environmental Factors in Schizophrenia. A Study of Schizophrenic Twins and their Families. Copenhagen: Munksgaard.Google ScholarPubMed
Fremming, K. H. (1947) Morbid Risk of Mental Diseases and Other Mental Abnormalities in an Average Danish Population. Copenhagen: Munksgaard.Google Scholar
Hauge, M., Harvald, B., Fischer, M., Gotlieb Jensen, K., Juel-Nielsen, N., Raebild, I., Shapiro, R. & Videbech, Th. (1968) The Danish Twin Register. Acta Geneticae Medicae et Gemellologiae, 17, 315–32.CrossRefGoogle ScholarPubMed
Juel-Nielsen, N. & Videbech, Th. (1970) A twin study of suicide. Acta Geneticae Medicae et Gemellologiae, 19, 307–10.Google Scholar
Kallmann, F. J. (1954) Genetic principles in manic-depressive psychosis. In Depression (eds Hoch, P. and Zubin, J.), pp 1–24. New York: Grune & Stratton.Google Scholar
Kallmann, F. J., De Porte, J., De Porte, E. & Feingold, L. (1949) Suicide in twins and only children. American Journal of Human Genetics, 1(2), 113–26.Google ScholarPubMed
Kringlen, E. (1967) Heredity and Environment in the Functional Psychoses. Oslo: Universitets-Forlaget.Google Scholar
Kraepelin, E. (1913) Psychiatric, VIII Auflage. Leipzig: Barth.Google Scholar
Leonhard, K. (1959) Aufteilung der endogenen Psychosen. Berlin: Akademie-Verlag.Google Scholar
Luxenburger, H. (1928) Vorläufiger Bericht über psychiatrische Serienuntersuchungen von Zwillingen. Zeitschrift für die Gesamte Neurologic und Psychiatric, 116, 296–326.Google Scholar
Perris, C. (1966) A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavica, Suppl 194.Google Scholar
Perris, C. (1973) The genetics of affective disorders. In Biological Psychiatry (ed. Mendels, J.), pp 383–415. New York: Wiley & Sons.Google Scholar
Price, J. (1968) The genetics of depressive behaviour. In Recent Developments in Affective Disorders—A Symposium (eds Coppen, A. and Walk, A.), pp 37–54. British Journal of Psychiatry Special Publication No. 2. Royal Medico-Psychological Association.Google Scholar
Rosanoff, A. J., Handy, L. M. & Plesset, I. R. (1934) The etiology of manic-depressive syndromes with special reference to their occurrence in twins. American Journal of Psychiatry, 91, 725–62.Google Scholar
Sainsbury, P. (1968) Suicide and depression. In Recent Developments in Affective Disorders—A Symposium (eds Coppen, A. and Walk, A.), pp 1–13. British Journal of Psychiatry Special Publication No. 2. Royal Medico-Psychological Association.Google Scholar
Shapiro, R. W. (1970) A Twin Study of Non-Endogenous Depression. Copenhagen: Munksgaard.Google Scholar
Slater, E. (1953) Psychotic and Neurotic Illnesses in Twins. M.R.C. Special Report Series No. 278. London: HMSO.Google Scholar
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders, pp 353–4. London: Oxford University Press.Google Scholar
Zerbin-Rüdin, E. (1969) Zur Genetik der depressiven Erkrankungen. In Das Depressive Syndrom (eds Hippius, H. and Selbach, H.), pp 37–56. Berlin: Urban & Swartzenberg.Google Scholar
Winokur, G. (1972) Types of depressive illness. British Journal of Psychiatry, 120, 265–6.CrossRefGoogle ScholarPubMed
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