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Cytogenetic Investigation in Twins with Manic-Depressive Disorders (22 Monozygotic and 27 Dizygotic Twin Pairs)

Published online by Cambridge University Press:  29 January 2018

Johannes Nielsen ,
Akira Homma  and
Aksel Bertelsen
Johannes Nielsen
Affiliation:
The Cytogenetic Laboratory and the Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark
Akira Homma
Affiliation:
The Cytogenetic Laboratory and the Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark
Aksel Bertelsen
Affiliation:
The Cytogenetic Laboratory and the Institute of Psychiatric Demography, Aarhus Psychiatric Hospital, Risskov, Denmark
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Summary

Chromosome examination was made in 22 monozygotic and 27 dizygotic twin pairs of whom one or both of each pair suffered or had suffered from manic-depressive disorder. We found a significantly higher frequency of chromosome variations among dizygotic twin pairs than was expected from population studies, but not in monozygotic pairs. There was no association between the chromosome variations and manic-depressive disorders. We found no greater intra-pair correlation in monozygotic twins compared with dizygotic twins as regards hypodiploidy, hyperdiploidy and unstable chromosome aberrations, which indicates that the aetiology of such aberrations is mainly of exogenic nature.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 4 , April 1977 , pp. 352 - 354
Copyright
Copyright © Royal College of Psychiatrists, 1977 

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