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Cyclic AMP Second-Messenger Signal Amplification in Depression

Published online by Cambridge University Press:  02 January 2018

Richard P. Ebstein ,
Bernard Lerer ,
Baruch Shapira ,
Zecharia Shemesh ,
Daniel G. Moscovich  and
Seth Kindler
Seth Kindler
Affiliation:
Jerusalem Mental Health Center, Ezrath Nashim Hospital
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Abstract

Beta-adrenergic-mediated cyclic AMP accumulation was reduced in lymphocytes obtained from depressed patients from that observed in an age- and sex-matched group of control subjects. Among the depressed patients, those not responding to treatment showed significantly lower pretreatment responses to isoproterenol compared with patients who exhibited significant clinical improvement during antidepressant treatment. Late-night (terminal) insomnia was significantly associated with the blunted response to beta-adrenergic stimulation. In depressed patients with the lowest isoproterenol response, the effect of forskolin (which acts distal to the receptor and directly stimulates the catalytic subunit) on cyclic AMP accumulation was also significantly decreased. This suggests that post-receptor modulations of signal amplification also play a role in the reduced response to beta-adrenergic stimulation in depression.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 152 , Issue 5 , May 1988 , pp. 665 - 669
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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