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A Critical Appraisal of X-Linked Bipolar Illness

Evidence for the Assumed Mode of Inheritance is Lacking

Published online by Cambridge University Press:  02 January 2018

Johannes Hebebrand
Johannes Hebebrand*
Affiliation:
Klinik für Kinder- und Jugendpsychiatrie, der Universität Marburg, Hans-Sachs-Strasse 6, 3550 Marburg, Germany
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Abstract

The major assumption underlying all X-linkage studies of bipolar disorder has been that a subgroup of manic–depressive illness follows an X-linked dominant mode of inheritance. An evaluation of the segregation patterns in the pedigrees that have been analysed for X-linkage over the past 20 years does not support this assumption, because the formal genetic criteria for an X-linked dominant mode of inheritance are virtually absent. Not a single pedigree has been ascertained in which the segregation pattern is suggestive of the assumed mode of inheritance. This is mainly because segregation ratios characteristic for X-linked dominant inheritance cannot be observed among the offspring of affected males.

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The British Journal of Psychiatry , Volume 160 , Issue 1 , January 1992 , pp. 7 - 11
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Copyright © The Royal College of Psychiatrists 

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